isibhengezo_sekhasi

118488-18-9 Fmoc-D-Tyr(tbu)-OH

118488-18-9 Fmoc-D-Tyr(tbu)-OH

Incazelo emfushane:

Ukubukeka Impushana emhlophe
MF C28H29NO5
MW 459.53
Ubumsulwa 98+


Imininingwane Yomkhiqizo

Isimo sezokuthutha
Kungaba kuzinga lokushisa elijwayelekile

Ncoma indlela yokuthumela
Ngomoya Ngomhlaba Ngasolwandle

Isimo sesitoreji:
Gcina endaweni emnyama, emkhathini ongangeni, izinga lokushisa legumbi

Impilo yeshelufu
Cishe iminyaka emi-2

Ubuncane be-oda Ubuningi:
1kg (ingxoxo)

Isitifiketi:I-COA, indawo encibilikayo, i-SpecificRotation [α]D20                      

Sizothumela noma iyiphi idatha oyifunayo.Ungabona idatha ngaphambili njengereferensi.

Ngemikhiqizo eyenziwe ngokwezifiso, sithumela idatha entsha kakhulu ngemuva kokuthi iphumile.

I-D-Ls(tfa)-NCA (2)

Omqondofana

I-FMOC-OT-BUTYL-D-TYROSINE;
I-FMOC-O-TERT-BUTYL-D-TYROSINE;
I-FMOC-D-TYR(TBU)-OH99%;
I-N-α-Fmoc-O-tert-butyl-D-tyrosine;
I-NALPHA-9-Fluorenylmethoxycarbonyl-O-tert-butyl-D-tyrosine;
I-9-fluorenylmethyloxycarbonyl-D-tyrosine(tert-butyl)-OH;
(R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoicacid;
I-Fmoc-D-Tyr(tBu)-OH(Fmoc-O-tert-butyl-D-tyrosine)

Ukupakisha kwangaphakathi

Zivame ukusetshenziselwa ukupakisha impushana.Kuya ngemfuneko yamakhasimende.Ukukugcina kukuhle ukufika lapho uya khona.Sizovala amabhodlela epulasitiki ngetheyiphu yepulasitiki emhlophe esikhaleni sezivalo.

Ukupakisha kwangaphakathi 2
Ukupakisha kwangaphakathi 1
Ukupakisha kwangaphakathi 3

ukupakisha kwangaphandle

Ukupakisha kwangaphandle kunzima.Futhi kunzima ukusika nokulimaza.Ingavikela imikhiqizo yakho ngokuphelele.Sizowela itheyiphu yepulasitiki ngaphandle ukuze silungise zonke izingxenye.Futhi uma kunesidingo, sizobadlwengula ngefilimu enwetshiwe ngaphandle.

Ukupakisha kwangaphandle 3
Ukupakisha kwangaphandle 2
Ukupakisha kwangaphandle 1

Izinhlelo zokusebenza

I-Fmoc-D-Tyr(tBu)-OH, eyaziwa nangokuthi i-Fmoc-O-tert-butyl-D-tyrosine, iphuma kokunye okushintshiwe kwe-amino acid enezici zamakhemikhali ezihlukile.Ithola izinhlelo zokusebenza ku-biochemistry, ukutholakala kwezidakamizwa, ukuhlanganiswa kwe-peptide, kanye nokuhlanganiswa kwe-organic.

Ucwaningo lwe-Biochemical:
I-Fmoc-D-Tyr(tBu)-OH ingasetshenziselwa ukutadisha isakhiwo nokusebenza kwamaprotheni.Ngenxa yokwakheka kwayo kwamakhemikhali athile, ingakwazi ukusebenzisana namanye ama-molecule, inikeze imininingwane ekusebenzisaneni kwamaprotheni-amaprotheni, ukusebenzisana kwamaprotheni-ligand, nokunye.
Ukutholwa Kwezidakamizwa:
Ekutholakaleni kwezidakamizwa, i-Fmoc-D-Tyr(tBu)-OH isebenza njengesihluthulelo esimaphakathi sokuhlanganiswa kwama-peptide asebenzayo ngokwebhayoloji nezidakamizwa ezisekelwe kumaprotheni.Ngokushintshwa kwamakhemikhali, izinhlanganisela ezinenani lemithi ezingase zilungiselwe ukuqhubeka nezifundo zesayensi yezemithi nezamakhemisi.
I-Peptide Synthesis:
I-Fmoc-D-Tyr(tBu)-OH idlala indima ebalulekile ekuhlanganiseni kwe-peptide yesigaba esiqinile.Ngenxa yeqembu layo lokuvikela i-Fmoc, ivumela ukuxhumana okusebenzayo kwe-amino acid kanye nokuvikela, okuvumela ukuhlanganiswa kwamaketanga e-peptide ngokulandelana nemisebenzi ethile.
I-Organic Synthesis:
Ku-organic synthesis, i-Fmoc-D-Tyr(tBu)-OH isebenza njengesakhiwo sokwakha ama-molecule ayinkimbinkimbi.Isebenzisa ukwakheka kwayo kwamakhemikhali athile, ingabhekana nokuhlangana kwamakhemikhali namanye ama-molecule, okuholela ekwakhekeni kwama- molecule ephilayo anemisebenzi efiselekayo.

imikhiqizo ehlobene

L-Tyr-OH I-D-Tyr-OH I-DL-Tyr
N-Me-Tyr (mina)-OH I-N-Me-Tyr (mina).HCL I-L-Tyr(tbu)-OH
L-Tyr-Otbu I-D-Tyr-Otbu I-Boc-N-Me-L-Tyr(tbu)-OH
Boc-Tyr-Otbu I-Boc-D-Tyr-Otbu I-Boc-DL-Tyr-Otbu
I-Boc-L-Tyr(tBu)-OH Boc-Tyr (Kodwa).Aib I-Fmoc-N-Me-Tyr(tBu)-OH
I-Fmoc-N-Me-D-Tyr(tBu)-OH I-Fmoc-L-Tyr(tBu)-OH I-Fmoc-D-Tyr(Et)-OH
Cbz-N-Me-Tyr(tbu)-OH I-Z-Tyr(tbu) Z-Tyr(tbu).DCHA

Ukuphakama

1. Sihlinzeka ngokwezifiso imikhiqizo oyidingayo.
2. Ikhwalithi ephezulu kanye nentengo yokuncintisana inganikezwa.
3.Sithembisa inkambo ephelele yokulandelela isevisi yakho.
4. Uhlu lwemibuzo yabahlinzeki kanye nemibhalo yezobuchwepheshe inganikezwa uma isicelo emva kokuhlangabezana nenani elithile.
5. Isevisi enhle yangemuva kokuthengisa noma isiqinisekiso : Noma yimuphi umbuzo wakho uzoxazululwa ngokushesha okukhulu.
6. Thumela imikhiqizo encintisanayo futhi uyithumele emazweni angaphandle ngobuningi njalo ngonyaka.
7.Isampula yamahhala enikezwa ukuhlola ikhwalithi ngaphambi kwanoma iyiphi inkokhelo.


  • Okwedlule:
  • Olandelayo:

  • Bhala umlayezo wakho lapha futhi usithumelele wona