I-China 130622-05-8 I-Tert-butoxycarbonyl-D-glutamic acid(methyl ester)-methyl ester Umkhiqizi kanye Nemboni |Jiayinglai

130622-05-8 I-Tert-butoxycarbonyl-D-glutamic acid(methyl ester)-methyl ester

Incazelo emfushane:

Ukubukeka	Amakristalu amhlophe kuya kokumhlophe noma impushana ecwebezelayo.
MF	I-C12H21NO6
MW	275.3
Ubumsulwa	98+

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Isimo sezokuthutha&indlela yokuthumela enconyiwe:
ngomoya, ngolwandle noma nge-express

Isimo sesitoreji:
Gcina endaweni emnyama, evalwe endaweni eyomile, Emazingeni Okushisa Egumbi

Ubuncane be-oda Ubuningi:
Ukuxoxisana

Isitifiketi:
I-COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyatholakala

Omqondofana

i-dimethyl(tert-butoxycarbonyl)-D-glutamate;
(R) -2-tert-Butoxycarbonylamino-pentanedioic acid dimethyl ester;
(Tert-Butoxy)Carbonyl D-Glu(OMe)-OMe (Isiraphu);
I-Boc-D-Glu(OMe)-OMe (Isiraphu);
i-dimethyl (2R) -2- [(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate;
I-Alogliptin Ukungcola 43;
1,5-dimethyl (2R)-2-{[(tert-butoxy)carbonyl]amino}pentanedioate

Ukupakisha kwangaphakathi

Ngokuvamile zisetshenziselwa ukupakisha impushana.Futhi zingavimbela ukukhanya kwelanga namanzi ukuba kungabi kubi.

ukupakisha kwangaphandle

Ibhokisi eliqinile lingavikela imikhiqizo yakho ukuthi ingaphahlazeka futhi ibe manzi.

Izinhlelo zokusebenza

I-Fluoroquinolones ine-spectrum ebanzi ye-antibacterial, umsebenzi oqinile we-antibacterial, ukusabela okungalungile okuphansi, ukungena kahle kwezicubu, i-bioavailability ephezulu yomlomo, isikhathi eside sokuphatha kanye nokuphatha okulula.Zivame ukusetshenziswa ekwelapheni izifo ezithathelwanayo ezifana nokutheleleka kwepheshana lokuphefumula kanye nokutheleleka kwe-urinary tract.Isakhiwo semithi elwa namagciwane i-fluoroquinolone ibonakala ngokuba khona kwe-fluorine endaweni yesithupha ye-nucleus yomzali we-quinolone.
Kodwa-ke, eminyakeni eyi-10 yamuva nje, ngenxa yengcindezi ekhethiwe evezwa ukusetshenziswa okubanzi kwalolu hlobo lwezidakamizwa, izinhlobo ezimelana nezidakamizwa ziyanda, ikakhulukazi eminyakeni yamuva nje, i-quinolone-resistant Streptococcus pneumoniae ine-cross-resistance, ekwazi ukumelana ne-penicillin, ama-macrolide antibiotic kanye ne-quinolone antibiotics.Ngasikhathi sinye, kwatholakala ukuthi amanye ama-fluoroquinolones angabangela ukwelulwa kwesikhawu se-QTc kwe-electrocardiogram, i-hepatotoxicity kanye ne-phototoxicity, okukhawulela ukusetshenziswa kwazo.
Ukuze unqobe lokhu kushiyeka okungenhla kwe-fluoroquinolones, kuyaphuthuma ukuthuthukisa izinhlanganisela ezintsha zesakhiwo ezinomsebenzi omuhle we-antibacterial, i-spectrum ebanzi ye-antibacterial kanye nokusabela okubi okungahle kube okuncane ngangokunokwenzeka ngokumelene namagciwane aphikisana nezidakamizwa eziningi.Uchungechunge lwemithi emisha esanda kuthuthukiswa ye-fluoroquinolone-free (NFQ) equkethe i-8-methoxyl ihlukile kuma-antibiotic e-fluoroquinolone ngoba ayinayo i-fluorine endaweni yesi-6 ye-nucleus yomzali we-quinolone, kodwa isenomsebenzi oqinile we-in vitro antibacterial.I-nemonoxacin iyi-NFQ entsha ekhethiwe ye-bacterial topoisomerase inhibitor.
Uma kuqhathaniswa nama-fluoroquinolones asemakethe njengamanje, i-Nenofloxacin imele isigaba esisha semithi yesakhiwo.I-nemonocacin (TG-873870), umuthi omusha we-quinolone owakhiwe yi-Procter & Gamble (P&G), ubonise umsebenzi obalulekile wokulwa namagciwane ngokumelene nezinhlobonhlobo zamagciwane abalulekile emitholampilo, okuhlanganisa i-Staphylococcus aureus kanye ne-Streptococcus pneumoniae engazweli emithini eminingi.Imiphumela yokuhlolwa kwamagundane anegciwane ibonise ukuthi umphumela we-antibacterial walo mkhiqizo wawunamandla kuneningi lama-quinolones amanje.Ngaphezu kwalokho, umkhiqizo unezakhiwo ezinhle kakhulu ze-pharmacokinetic futhi ubekezelelwa kahle.

imikhiqizo ehlobene

I-Fmoc-Gly-glu(otbu)-oh	I-Boc-D-Glu(OBzl)-Oet
HL-Glu-OH	I-Boc-D-Glu(Obzl)-OH
I-HD-Glu-OH	I-Boc-D-Glu(Ome)-OH
I-DL-Glu-OH	I-Boc-D-Glu(Ome)-OH.DCHA
I-DL-Glu-OH.H2O	I-Boc-Glu(OBzl)-Obzl
I-L-Glu(Obzl)-NCA	I-Boc-L-Glu-OBzl
I-D-Glu(Obzl)-NCA	I-Boc-D-Glu-Obzl
I-DL-Glu(Obzl)-NCA	I-Boc-D-Glu-Otbu-OH
I-L-Glu-Obzl	I-Boc-D-Glu(OMe)-OMe
I-Tos-Glu-Obzl	I-Boc-D-Glu(Obzl)-Obzl
I-L-Glu(Ome)-Obzl.TOS	Boc-L-Glu(Ome)-Ome
I-AC-Glu(OtBu)	I-Boc-L-Glu(OMe)-OH
I-DL-Glu(Ome)	I-Boc-L-Glu(OBzl)-OH
I-HD-Glu(OMe)-OH	I-Boc-Glu-Otbu
I-HL-Glu(OMe)-OH	I-Boc-L-Glu(Obzl)-Ome
I-L-Glu(Obzl)	I-Boc-L-Glu(Oet)
I-HL-Glu(OtBu)-OH	I-Fmoc-L-Glu-OH
I-HL-Glu(OEt)-OH	I-Fmoc-D-Glu-OH
I-L-Glu(Otbu)-Otbu-OH	I-Fmoc-D-Glu(Ome)-OH
I-HD-Glu(OBzl)-OH	I-Fmoc-L-Glu(OcHx)-OH
I-D-Glu-OBzl	I-Fmoc-L-Glu(OMe)-OH
I-HL-Glu(Ome)-Otbu.Hcl	I-Fmoc-L-Glu(OtBu)-OH
I-D-Glu(Obzl)-Otbu.HCL	I-Fmoc-D-Glu(OBzl)-OH
I-D-Glu(OtBu)-OtBu•HCl	I-Fmoc-D-Glu(Otbu)-OH
I-L-Glu(OcHx).hcl	I-Fmoc-L-Glu-OtBu
I-HL-Glu(OBzl)-OBzl.HCl	I-Fmoc-L-Glu(OBzl)-OH
I-HL-Glu-OBzl.HCl	I-Fmoc-L-Glu(Cbz-yebo)
I-D-Glu(OBzl)-OBzl.HCl	I-Fmoc-N-Me-L-Glu(Otbu)-OH
I-DL-Glu(Ome)-Ome.Hcl	I-Fmoc-glu-obzl
I-HL-Glu(OtBu)-OtBu•HCl	Cbz-L-Glu-OH
I-HL-Glu(OMe)-OMe.HCl	Cbz-D-Glu-OH
I-L-Glu(Obzl)-OME.HCL	I-ZL-Glu-OBzl
I-HL-Glu(OEt)-OEt·HCl	I-ZD-Glu-OBzl
I-L-Glu(Obzl)-Otbu.HCl	I-Cbz-L-Glu-Otbu
I-HD-Glu(OMe)-OMe·HCl	I-Cbz-D-Glu(ome)
I-N-Pht-Glu	I-Cbz-L-Glu(OBzl)-OH
I-Boc-L-Glu-OH	I-Cbz-L-Glu(Otbu)
I-Boc-D-Glu-OH	I-Cbz-L-Glu(Ome)
I-Boc-Glu(obzl)-NH2	I-Cbz-D-Glu(OtBu)-OH
I-Boc-Glu (trt)-OH	I-Cbz-L-Glu(Ome)-OtBu
I-Boc-L-Glu(OcHx)-OH	Cbz-L-Glu-OBzl.DCHA
I-Boc-L-Glu(OtBu)-OH	I-Cbz-L-Glu(Oet)-OH
I-Boc-Glu(Osu)-Otbu	I-Boc-Glu-Otbu (i-Osu)

Ukuphakama

1. Isevisi ye-R&D iyatholakala
2. Umkhiqizi oqinisekisiwe we-ISO, isiqinisekiso sekhwalithi
I-3.Inkambo ephelele yenkonzo yokulandelela ngesikhathi sokukhiqiza
I-4.Izindleko eziphezulu
5.Imibhalo yesitifiketi sekhwalithi enikeziwe ngokwesicelo sekhasimende ngalinye
I-6.Isevisi enhle emva kokuthengisa, ukugcina ubuhlobo obuseduze nekhasimende
7.Insiza egcwele yokusiza ukwehlisa izindleko zokuthumela
8.Isampula yamahhala enikelwe ukuhlola ikhwalithi ngaphambi kwanoma iyiphi inkokhelo
9.Isikhathi sokukhokha okuxoxiswana ngaso
10.Amakhasimende e-Assit abhekana nezindaba zaseShayina