I-China 13590-42-6 H-Asp(OBzl)-NCA Umkhiqizi kanye Nemboni |Jiayinglai

13590-42-6 H-Asp(OBzl)-NCA

Incazelo emfushane:

Ukubukeka	Impushana emhlophe
MF	I-C12H11NO5
MW	249.22
Ubumsulwa	98+

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Isimo sezokuthutha
Cold chain transportation (-18℃～-22℃)

Ncoma indlela yokuthumela
Ngomoya Ngomhlaba Ngasolwandle

Cold chain transportation (-18℃～-22℃)

Isimo sesitoreji:
Umkhathi ongenayo,Gcina efrijini, ngaphansi kuka-20°C

Impilo yeshelufu:
Izinyanga eziyisi-6 ukuya onyakeni owodwa

Ubuncane be-oda Ubuningi:
10gm(ingxoxo)

Isitifiketi:I-COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyatholakala
Sivamise ukuba ne-HPLC, AT, TLC.Uma ngempela ufuna ukuthi sihlole i-HNMR, sicela uqaphele.

Omqondofana

i-benzyl (1,2,3,4-tetrahydro-2,5-dioxo-1,3-oxazol-4-yl) i-acetate;
2-[(4S)-2,5-Dioxooxazolidine-4-yl]i-acetic acid benzyl ester;
i-Benzyl-L-aspartic acid N-carboxyanhydride;
(4S) -2,5-Dioxooxazolidine-4-acetic acid benzyl ester;
(4S)-4-(Benzyloxycarbonylmethyl)oxazolidine-2,5-dione;
(4S) -4-[2-(Benzyloxy)-2-oxoethyl]oxazolidine-2,5-dione;
3-(Benzyloxycarbonyl)-N-carboxy-L-alanine anhydride;
(S) -2,5-Dioxo-4-oxazolidineacetic acid phenylmethyl ester;
I-H-ASP(OBZL)-NCA;
L-aspartic acid 4-benzyl ester N-carboxyanhydride;

Ukupakisha kwangaphakathi

Zisetshenziselwa ukupakisha inani elincane lemikhiqizo.(1g kuya ku-10kg).Bese uwafaka emabhokisini aqinile amakhadibhodi.

ukupakisha kwangaphandle

Eyokuqala ivame ukusetshenziselwa ukupakisha inani elincane lemikhiqizo.Eyesibili isetshenziselwa ukupakisha ezinkulu.(15kg kuya ku-25kg).Futhi sizofaka ilebula ekuqondeni phambili.Bese unamathisele irisidi ye-warehouse esivalweni.

Izinhlelo zokusebenza

Ucwaningo lwe-Biochemical:
Ku-peptide synthesis, i-H-Asp(OBzl)-NCA isebenza njengesakhiwo esibalulekile sokuhlanganiswa kwamaketanga e-peptide aqukethe ukulandelana kwe-aspartic acid.
Iqembu layo le-benzyl ester lisebenza njengeqembu elivikelayo, elivumela ukwethulwa kokuguqulwa kwamakhemikhali athile ngesikhathi sokuhlanganiswa kweketango le-peptide, elingase lisuswe ngaphansi kwezimo ezifanele ukuze kutholwe ukulandelana kwe-aspartic acid edingekayo.
Ocwaningweni lokuguqulwa kwamaprotheni noma i-peptide, i-H-Asp(OBzl)-NCA ingasetshenziswa ukwethula ukuguqulwa kwamakhemikhali okuthile ukuze kuphenywe ukuthi lezi zinguquko ziwuthinta kanjani umsebenzi webhayoloji noma ukusebenzisana namanye ama-molecule ephrotheni noma e-peptide.
Ukutholwa Kwezidakamizwa:
I-H-Asp(OBzl)-NCA ingasebenza njengesandulela sokwenziwa noma esimaphakathi samangqamuzana ezidakamizwa, okuvumela ukwethulwa kwezakhi zamakhemikhali ezithile ngesikhathi sokuklanywa kwezidakamizwa ukuze kutholwe abantu abasebenzisa izidakamizwa ngemisebenzi yebhayoloji.
Ngokusabela nezinye izingcezu zezidakamizwa noma ama-molecule asebenzayo, kungasiza ukuhlanganiswa kwezidakamizwa ezisekelwe ku-peptide noma izinhlanganisela ze-heterocyclic ezinemiphumela ethile yokwelapha.
Ezinqubweni zokutholwa kwezidakamizwa, i-H-Asp(OBzl)-NCA ingasetshenziswa futhi ekuhlolweni komphumela ophezulu kanye nokuhlolwa komsebenzi webhayoloji ukuze kuhlolwe imisebenzi yokulandelana kwe-peptide ehlukene noma amakhandidethi ezidakamizwa.
Imboni Yezemithi:
Embonini yezemithi, i-H-Asp(OBzl)-NCA isebenza njengempahla eluhlaza noma emaphakathi ukuze kukhiqizwe izidakamizwa ze-peptide ezisebenzayo.
Ngokuhlangana kwe-condensation namanye ama-amino acid noma izingcezwana zezidakamizwa, kungenza kube lula ukuhlanganiswa kwezidakamizwa ze-peptide ngemisebenzi ethile yebhayoloji, njengama-antibiotics, amahomoni, ama-enzyme inhibitors, nokunye.
Iqembu le-benzyl ester elikhona esakhiweni salo livikela i-carboxylic acid ye-aspartic acid, ibambe iqhaza ekuzinzeni nasekusebenzeni kabusha kweketango le-peptide ngesikhathi sokuhlanganiswa.

imikhiqizo ehlobene

I-L-Ls(tfa)-NCA	I-Sar-NCA	I-L-Val-NCA
Lys(Cbz)-NCA	I-Gly-NCA	I-L-Leu-NCA
I-D-Ls(Cbz)-NCA	I-L-Ala-NCA	I-D-Leu-NCA
I-L-Tyr-NCA	I-D-Ala-NCA	Ile-NCA
I-D-Tyr-NCA	L-Phe-NCA	Orn (Cbz)-NCA
I-HD-Asp(OBzl)-NCA	I-L-Glu(Obzl)-NCA
I-D-Glu (Obzl)-NCA	I-DL-Glu(Obzl)-NCA

Ukuphakama

1. Sihlinzeka ngokwezifiso imikhiqizo oyidingayo.
2. Ikhwalithi ephezulu kanye nentengo yokuncintisana inganikezwa.
3.Sithembisa inkambo ephelele yokulandelela isevisi yakho.
4. Uhlu lwemibuzo yabahlinzeki kanye nemibhalo yezobuchwepheshe inganikezwa uma isicelo emva kokuhlangabezana nenani elithile.
5. Isevisi enhle yangemuva kokuthengisa noma isiqinisekiso : Noma yimuphi umbuzo wakho uzoxazululwa ngokushesha okukhulu.
6. Thumela imikhiqizo encintisanayo futhi uyithumele emazweni angaphandle ngobuningi njalo ngonyaka.
7.Isampula yamahhala enikezwa ukuhlola ikhwalithi ngaphambi kwanoma iyiphi inkokhelo.

Okwedlule: 2224-52-4 L-Ala-NCA

Olandelayo: 2389-45-9 Boc-L-Ls(Cbz)-OH

Bhala umlayezo wakho lapha futhi usithumelele wona