isibhengezo_sekhasi

1491158-62-3 Fmoc-Ls(Pal-Glu-OtBu)-OH

1491158-62-3 Fmoc-Ls(Pal-Glu-OtBu)-OH

Incazelo emfushane:

Ukubukeka Impushana emhlophe ukuya kokumhlophe
MF I-C46H69N3O8
MW 792.06
Ubumsulwa 98+


Imininingwane Yomkhiqizo

Isimo sezokuthutha
Kungaba kuzinga lokushisa elijwayelekile

Ncoma indlela yokuthumela
Ngomoya Ngomhlaba Ngasolwandle

Isimo sesitoreji:
Gcina endaweni emnyama, emkhathini ongangeni, izinga lokushisa legumbi

impilo yeshelufu
Cishe iminyaka emi-2

Ubuncane be-oda Ubuningi:
1kg (ingxoxo)

Isitifiketi:I-COA, indawo encibilikayo, i-SpecificRotation [α]D20                      

Sizothumela noma iyiphi idatha oyifunayo.Ungabona idatha ngaphambili njengereferensi.

Ngemikhiqizo eyenziwe ngokwezifiso, sithumela idatha entsha kakhulu ngemuva kokuthi iphumile.

I-D-Ls(tfa)-NCA (2)

Omqondofana

I-Fmoc-Ls(Pal-Glu-OtBu)-OH;

N2--[(9H-Fluoren-9-ylmethoxy)carbonyl]-N6-[N-(1-oxohexadecyl)-L-gamma-glutamyl]-L-lysine1'-(1,1-dimethylethyl)ester;

(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-6-((S)-5-(Tert-Butoxy)-5-Oxo-4-Palmitamidopentanamido)HexanoicAcid;

(9H-Fluoren-9-yl)MethOxy]CarbonyLys(Pal-Glu-OtBu)-OH;

I-N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-(N-alpha'-palmitoyl-L-glutamic-acidalpha'-t-butylester)-L-lysine;

I-Fmoc-L-Ls(Palm-L-Glu-OtBu)-OH;

(2S)-6-[(4S)-5-(tert-butoxy)-4-hexadecanamido-5-oxopentanamido]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoicacid;

L-Lysine,N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N6-[N-(1-oxohexadecyl)-L-γ-glutamyl]-,1'-(1,1-dimethylethyl)ester

Ukupakisha kwangaphakathi

Zivame ukusetshenziselwa ukupakisha impushana.Kuya ngemfuneko yamakhasimende.Ngakho-ke, sitshele ngenkani yakho ngaphambi kokupakisha uma unezicelo ezikhethekile.

Ukupakisha kwangaphakathi 2
Ukupakisha kwangaphakathi 1
Ukupakisha kwangaphakathi 3

ukupakisha kwangaphandle

1kg kuya ku-25kg Ukupakisha kwangaphandle kunzima.Futhi kunzima ukusika nokulimaza.Ingavikela imikhiqizo yakho ngokuphelele.

Ukupakisha kwangaphandle 3
Ukupakisha kwangaphandle 2
Ukupakisha kwangaphandle 1

Izinhlelo zokusebenza

I-Fmoc-Ls(Pal-Glu-OtBu)-OH iyinhlanganisela enesakhiwo esithile samakhemikhali esithola ukusetshenziswa okubanzi emikhakheni ye-bioscience kanye nocwaningo lwezemithi nokuthuthukiswa.Ngokucacile, ingasetshenziswa njengesixhumi se-ADC esonakalisayo sokuhlanganiswa kwama-antibody-drug conjugates (ADCs).Ama-ADC yimithi ehlanganisa ama-molecule ezidakamizwa namasosha omzimba ngokusebenzisa izixhumanisi ezithile, okuvumela ukukhomba okunembayo kanye nokwelashwa kwezifo.Ukwengeza, i-Fmoc-Ls(Pal-Glu-OtBu)-OH isebenza njengesixhumi se-PROTAC esisekelwe kumaketanga e-alkyl okuhlanganiswa kwama-PROTAC.Ama-PROTAC ama-molecule angadala ukuwohloka kwamaprotheni okuhlosiwe, azuze imiphumela yokwelapha ngokwehlisa amaprotheni ahlobene nezifo.

Ngaphezu kwalokho, izinkampani ezichwepheshile ze-biotechnology, njenge-Shanghai Jinpan Biotechnology Co., Ltd., zihlinzeka ngalolu hlobo lwenhlanganisela ukuze zisekele umsebenzi wocwaningo lwesayensi yezempilo kanye nabacwaningi bemithi.Lezi zinkampani zivame ukugxila ekuboniseni izindlela kanye nezindawo zocwaningo lwezifo, ezihlinzeka abacwaningi ngama-molecule e-bioactive aphezulu, ama-inhibitors, ama-agonists, ama-inhibitors athile, imitapo yolwazi ehlanganisiwe, namaprotheni aphinde ahlanganiswe.

imikhiqizo ehlobene

Lys(Fmoc)-OH H-Ls(Ac)-OH I-Ac-Lys-OH Fmoc-L-Lys-OH·HCl
Cbz-L-Lys-OH Fmoc-Lys-Ome·HCl I-Fmoc-L-Ls(Boc)-OH I-Fmoc-L-Ls(Fmoc)-OH
Z-DL-Lys(cbz)-OH I-Cbz-L-Lys(Fmoc)-OH

Kungani Khetha Thina

1. Mayelana ne-MOQ: Singayilungisa ngokuvumelana nemfuneko yakho.
2. Mayelana nesampula: Isampula idinga imali yesampula, okungaba yimpahla ongayilanda noma ongayikhokha kithi kusengaphambili.
3. I-Mold workshop, ingenziwa ngezifiso ngokusho kwenani lamamodeli.
4. Sinikeza isevisi engcono kakhulu.Ithimba labadayisi abanolwazi selisebenzela wena.
5. Mayelana nokushintshisana: Ngicela ungithumele i-imeyili noma ungixoxele ngesikhathi esivumelana nawe.


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