isibhengezo_sekhasi

15776-11-1 Met-NCA

15776-11-1 Met-NCA

Incazelo emfushane:

Ukubukeka Amakristalu amhlophe kuya kokumhlophe noma impushana ecwebezelayo.
MF I-C6H9NO3S
MW 175.21
Ubumsulwa 98+


Imininingwane Yomkhiqizo

Isimo sezokuthutha&indlela yokuthumela enconyiwe:
Ngomoya, ngolwandle noma nge-express

Isimo sesitoreji:
Umkhathi ongenayo,Gcina efrijini, ngaphansi kuka-20°C

Ubuncane be-oda Ubuningi:
Ukuxoxisana

Isitifiketi:
I-COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyatholakala

I-D-Ls(tfa)-NCA (2)

Omqondofana

(S)-4-(2'-METHYLTHIOETHYL)OXAZOLIDINE-2,5-DIONE;

L-Met-NCA;

L-Methionine N-carboxyanhydride;

2,5-Oxazolidinedione, 4-[2-(methylthio)ethyl]-, (4S)-;

Ukupakisha kwangaphakathi

Ngokuvamile zisetshenziselwa ukupakisha impushana.Futhi zingavimbela ukukhanya kwelanga namanzi ukuba kungabi kubi.

Ukupakisha kwangaphakathi 2
Ukupakisha kwangaphakathi 1
Ukupakisha kwangaphakathi 3

ukupakisha kwangaphandle

Ibhokisi eliqinile lingavikela imikhiqizo yakho ukuthi ingaphahlazeka futhi ibe manzi.

Ukupakisha kwangaphandle 3
Ukupakisha kwangaphandle 2
Ukupakisha kwangaphandle 1

Izinhlelo zokusebenza

I-Peptide Synthesis: I-Met-NCA iyasebenza kakhulu futhi ingasetshenziswa njengebhlokhi yokwakha ye-peptide synthesis.Ihlangana kahle nama-amine ukwenza amabhondi e-peptide, ivumela ukwakhiwa kwama-peptide ngokulandelana okuqondile kanye nezakhiwo.Le ndlela iwusizo ikakhulukazi ekuhlanganiseni ama-peptide asebenzayo ezinto eziphilayo angasetshenziswa ocwaningweni lwezemithi noma njengezokwelapha.

Ukutholwa Nokuthuthukiswa Kwezidakamizwa: I-Methionine iyi-amino acid ebalulekile edlala indima ebalulekile ezinqubweni zebhayoloji.Ngokuhlanganisa i-Met-NCA kuma-molecule ezidakamizwa, abacwaningi bangakwazi ukwethula izinsalela ze-methionine ezingase zithuthukise ukusebenza kwe-bioactivity, ikhono lokukhomba, noma ukuzinza kwezidakamizwa.Le ndlela ingaholela ekutholakaleni kwemithi yokwelapha emisha enamaphrofayili athuthukisiwe emithi.

Izicelo Zesayensi Yezinto Ezibalulekile: I-Met-NCA ingasetshenziswa futhi ekuhlanganiseni ama-polymers nezinto ezisebenza ngokusebenza okusekelwe ku-methionine.Lezi zinto ezisetshenziswayo zingase zibonise izici ezihlukile ezifana ne-biocompatibility, i-biodegradability, noma ukusebenzisana okuthile namasistimu ebhayoloji.Zingasetshenziswa kubunjiniyela bezicubu, umuthi ovuselelayo, noma ukuthuthukiswa kwama-biomaterials wezicelo zezokwelapha.

I-Bioconjugation kanye Nokuguqulwa Kwamaprotheni: I-Met-NCA ingasetshenziswa njenge-reagent yokusabela kwe-bioconjugation, okuvumela ukunamathiselwa kwama-molecule ahlukahlukene noma amaqembu asebenzayo kumaprotheni noma ama-peptide.Leli khono lenza ukuguqulwa kwamaphrotheni anezakhiwo ezifiselekayo, njengokuncibilika okuthuthukisiwe, ukuzinza, noma ikhono lokukhomba.Ukusabela kwe-Bioconjugation kusetshenziswa i-Met-NCA kungasetshenziswa ekuthuthukisweni kokwelapha okusekelwe kumaprotheni, ama-biosensors, noma amathuluzi okuxilonga.

Izifundo ze-Biochemical and Cellular: Ikhono lokuhlanganisa ama-peptide namaprotheni aqukethe izinsalela ze-methionine usebenzisa i-Met-NCA inikeza ithuluzi elinamandla lezifundo ze-biochemical kanye namaselula.Abacwaningi bangasebenzisa la ma-molecule ukuze baphenye ukusebenzisana kwamaprotheni-amaprotheni, i-enzyme kinetics, noma izindlela zokubonisa amaselula.I-Met-NCA-derived peptides ingasetshenziswa futhi njengama-probes noma ama-inhibitors ukuze kufundwe izinqubo zebhayoloji nezindlela zezifo.

imikhiqizo ehlobene

I-L-Ls(Boc) I-Boc-Ls(Cbz)-Ol Z-Lys(boc)-Ala-Ala-OBzl I-Fmoc-L-Ls(Fmoc)-OH
Lys(Fmoc)-OH I-Boc-Ls(AC) L-Lys-oet.2HCl I-Fmoc-D-Ls(Boc)-OH
L-Ls(Cbz)-OH I-Boc-L-Ls(Cbz)-OH I-D-Lys-Ome.2Hcl I-Fmoc-L-Ls(Boc)-OH
I-D-Ls(cbz)-OH I-Boc-L-Ls(Boc)-OSu I-HL-Lys(cbz)-OBzl•HCl Fmoc-L-Lys-OH·HCl
H-Ls(Ac)-OH I-Boc-L-Ls(Boc)-OH·DCHA L-Lys(cbz)-Ome.Hcl Fmoc-Lys-Ome·HCl
Lys(tfa)-OH I-Boc-D-Ls(Boc)-OH lys(Cbz)-Otbu.HCl Fmoc-D-Ls-OH·HCl
I-D-Ls(tfa)-OH I-Boc-L-Ls(Cbz)-OMe I-D-Ls(Cbz)-OtBu.HCl I-Cbz-Ls(tfa)-OH
I-D-Ls (tfa)-NCA I-Boc-D-Ls(Cbz)-OH L-Lys.2Hcl I-Cbz-lys (cbz)-osu
I-L-Ls(tfa)-NCA I-Boc-L-Ls(Cbz)-OH·DCHA L-Lys-Ome.2Hcl Cbz-L-Ls(Cbz).DCHA
Lys(Cbz)-NCA I-Boc-L-Ls(Fmoc)-OH H-Lys-Lys.3HCl Cbz-L-Lys-OH
I-D-Ls(Cbz)-NCA I-Fmoc-L-Ls(tfa)-OH I-lys-obzl.2hcl I-Cbz-L-Ls(Cbz)-OH
ZL-Lys(Boc).DCHA I-Fmoc-L-Ls(DDC) I-D-Ls(Fmoc).HCl I-Cbz-Ls(AC)-OH
I-Ac-Lys-OH I-Fmoc-D-Ls(Cbz)-OH Lys(Fmoc).HCl Cbz-Ls(BOC)-ome
I-AC-Ls(Boc)-NH2 I-Fmoc-D-Ls(Fmoc)-OH I-D-Ls.Hcl I-Cbz-Ls(Boc)-Otbu
I-AC-Ls(Boc)-OH I-Fmoc-L-Ls(Cbz) D,L-Lys.Hcl I-Cbz-L-Ls(BOC)-OH
I-H-Ls(Cbz)-OtBu I-Fmoc-L-Ls(AC) L-Lys.HCl I-Cbz-L-Lys(Fmoc)-OH
I-Boc-Ls (Cbz).DCHA Cbz-L-Lys-Ome.Hcl I-Boc-L-Lys-OH Cbz-L-Lys-obzl.Hcl
I-Boc-Ls(tfa)-OH Z-DL-Lys(cbz)-OH    

Ukuphakama

1. Isevisi ye-R&D iyatholakala
2. Umkhiqizi oqinisekisiwe we-ISO, isiqinisekiso sekhwalithi
I-3.Inkambo ephelele yenkonzo yokulandelela ngesikhathi sokukhiqiza
I-4.Izindleko eziphezulu
5.Imibhalo yesitifiketi sekhwalithi enikeziwe ngokwesicelo sekhasimende ngalinye
I-6.Isevisi enhle emva kokuthengisa, ukugcina ubuhlobo obuseduze nekhasimende
7.Insiza egcwele yokusiza ukwehlisa izindleko zokuthumela
8.Isampula yamahhala enikelwe ukuhlola ikhwalithi ngaphambi kwanoma iyiphi inkokhelo
9.Isikhathi sokukhokha okuxoxiswana ngaso
10.Amakhasimende e-Assit abhekana nezindaba zaseShayina


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