isibhengezo_sekhasi

1799443-50-7 Fmoc-N-Me-D-Tyr(tBu)-OH

1799443-50-7 Fmoc-N-Me-D-Tyr(tBu)-OH

Incazelo emfushane:

Ukubukeka impushana emhlophe
MF I-C29H31NO5
MW 473.56
Ubumsulwa 98+


Imininingwane Yomkhiqizo

Isimo sezokuthutha
Kungaba kuzinga lokushisa elijwayelekile

Ncoma indlela yokuthumela
Ngomoya Ngomhlaba Ngasolwandle

Isimo sesitoreji:
Gcina endaweni emnyama, emkhathini ongangeni, izinga lokushisa legumbi

Impilo yeshelufu
Cishe iminyaka emi-2

Ubuncane be-oda Ubuningi:
1kg (ingxoxo)

Isitifiketi:I-COA, indawo encibilikayo, i-SpecificRotation [α]D20                      

Sizothumela noma iyiphi idatha oyifunayo.Ungabona idatha ngaphambili njengereferensi.

Ngemikhiqizo eyenziwe ngokwezifiso, sithumela idatha entsha kakhulu ngemuva kokuthi iphumile.

I-D-Ls(tfa)-NCA (2)

Omqondofana

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(4-(tert-butoxy)phenyl)propanoicacid;

(9H-Fluoren-9-yl)MethOxy]CarbonylN-Me-D-Tyr(tBu)-OH;

(2R)-3-[4-(tert-butoxy)phenyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)propanoicacid;

(2R) -2- [9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3- [4- [(2-methylpropan-2-yl)oxy]phenyl]propanoicacid;

I-N-Fmoc-N-methyl-O-tert-butyl-D-tyrosine;

I-D-Tyrosine,O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-

Ukupakisha kwangaphakathi

Zivame ukusetshenziselwa ukupakisha impushana.Kuya ngemfuneko yamakhasimende.Ngakho-ke, sitshele ngenkani yakho ngaphambi kokupakisha uma unezicelo ezikhethekile.

Ukupakisha kwangaphakathi 2
Ukupakisha kwangaphakathi 1
Ukupakisha kwangaphakathi 3

ukupakisha kwangaphandle

1kg kuya ku-25kg Ukupakisha kwangaphandle kunzima.Futhi kunzima ukusika nokulimaza.Ingavikela imikhiqizo yakho ngokuphelele.

Ukupakisha kwangaphandle 3
Ukupakisha kwangaphandle 2
Ukupakisha kwangaphandle 1

Izinhlelo zokusebenza

I-Fmoc-N-Me-D-Tyr(TBu)-OH, eyaziwa nangokuthi i-N-α-(9-fluorenylmethoxycarbonyl)-N-α-methyl-D-tyrosine tert-butyl ester, iphuma e-amino acid evikelwe evame ukusetshenziswa. ku-solid-phase peptide synthesis.Le nhlanganisela ihlanganisa iqembu elivikelayo le-Fmoc le-amino terminus ne-tert-butyl (TBu) ester evikela i-phenolic hydroxyl iqembu le-D-tyrosine.

Iqembu le-Fmoc, njengoba kushiwo ngaphambili, lizinzile futhi liyancibilika kuzincibilikisi zemvelo, okulenza lilungele ukuhlanganiswa kwe-peptide.Ingasuswa kalula ngaphansi kwezimo ze-alkaline, okuvumela ukuhlangana okulandelanayo kwama-peptide kuzisekelo eziqinile.I-tert-butyl ester, ngakolunye uhlangothi, ivikela iqembu le-phenolic hydroxyl ye-D-tyrosine, iqinisekisa ukuzinza nokuhlanzeka kwayo ngesikhathi senqubo yokuhlanganisa.

Ukusetshenziswa okuyinhloko kwe-Fmoc-N-Me-D-Tyr(TBu)-OH kusekulungiseni ama-peptide aqukethe i-D-tyrosine.Ngokusebenzisa le nto ephuma ku-amino acid, abacwaningi bangakwazi ukwethula i-D-tyrosine ngawo womabili amaqembu e-amino ne-phenolic hydroxyl avikelwe ekulandeleni kwawo ama-peptide.Lokhu kunikeza ukulawula okunembile phezu kwesakhiwo se-peptide futhi kusiza ukwethulwa kwamanye ama-amino acid nokuguqulwa ezindaweni ezithile ngaphakathi kweketango le-peptide.

I-D-Tyrosine iyi-amino acid engeyona eyemvelo engafakwa kuma-peptide ukuze kufundwe izici zawo zebhayoloji noma ukwenza ama-peptide analogue anemisebenzi eguquliwe.Ama-peptide aqukethe i-D-tyrosine angase abe nemisebenzi ehlukene yebhayoloji uma kuqhathaniswa nozakwabo be-L-tyrosine, ngenxa yomehluko we-stereochemical phakathi kwama-amino acid amabili.

imikhiqizo ehlobene

N-Me-Tyr(Me)-OH.HCl I-Boc-N-Me-L-Tyr(tbu)-OH I-Fmoc-N-Me-L-Tyr(tBu)-OH Cbz-N-Me-Tyr(tbu)-OH
FMOC-N-Me-D-Tyr(mina)-OH I-Boc-N-Me-L-Tyr(bzl)-OH I-Fmoc-N-Me-L-Tyr(bzl)-OH I-Boc-N-Me-D-Tyr(bzl)-OH

Kungani Khetha Thina

1. Mayelana ne-MOQ: Singayilungisa ngokuvumelana nemfuneko yakho.
2. Mayelana nesampula: Isampula idinga imali yesampula, okungaba yimpahla ongayilanda noma ongayikhokha kithi kusengaphambili.
3. I-Mold workshop, ingenziwa ngezifiso ngokusho kwenani lamamodeli.
4. Sinikeza isevisi engcono kakhulu.Ithimba labadayisi abanolwazi selisebenzela wena.
5. Mayelana nokushintshisana: Ngicela ungithumele i-imeyili noma ungixoxele ngesikhathi esivumelana nawe.


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