22254-24-6 8-Isopropylatropinium bromide

I-Ipratropium bromide yaziwa nangokuthi i-Haizhupanidine, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropine bromide, isopropyl atropine bromide, ipratropine bromide, ipratropium bromide, ne-ipratropium bromide.Kuyimpushana emhlophe ecwebezelayo enokunambitheka okubabayo.Iphoyinti lokuncibilika 232 ℃-233 ℃.Incibilika emanzini, inyibilika kancane ku-ethanol, ayincibiliki kwezinye izinyibilikisi eziphilayo.Igama lamakhemikhali: I-Brominated α- (hydroxymethyl) -phenylacetic acid - 8-methyl-8-isopropyl - azocyclic [3,2,1] -3-octyl ester.Kuyisidakamizwa se-anticholinergic, esinomphumela oqinile wokuphumula emisipha ebushelelezi ye-bronchial kanye nomphumela we-antiasthmatic ku-chronic obstructive pulmonary disease.Umthelela wayo usobala, umphumela osheshayo kanye nobude besikhathi eside.I-Ipratropium bromide iphinde ilawule ukukhishwa kwezindlala zamafinyila futhi ithuthukise ukunyakaza kwe-ciliary, ngaleyo ndlela yehlise ukuvinjwa kwesikhwehlela ukuze kuthuthukiswe umoya.Phakathi naleso sikhathi, ukunciphisa isikhwehlela nakho kunciphisa i-bronchospasm ebangelwa ukucasuka kwe-bronchi.Ukuvimbela nokwelashwa kwe-asthma ye-bronchial kanye ne-asthmatic chronic bronchitis, ikakhulukazi ezigulini ezingakwazi ukubekezelela ukusetshenziswa kwe-β-agonist muscle tremor, tachycardia.Lo mkhiqizo ungasetshenziswa uhlanganiswe nama-beta-agonists ukuthuthukisa ukusebenza kahle komunye nomunye, njengokuhlanganiswa ne-finoterol ukwenza i-aerosol (BERODU -- AL) yesifuba somoya, i-bronchitis engapheli kanye ne-emphysema.Uma kuqhathaniswa nama-β-adrenergic receptor stimulants (isb, isopropyl epinephrine), lo mkhiqizo unemiphumela engemihle yenhliziyo nemithambo yegazi, futhi uma uqhathaniswa nezivuseleli ze-β2-receptor (isb., i-Suquanling), lo mkhiqizo unomphumela onamandla wokulawula umthamo wephlegm.
Futha ukuhogela.40 ~ 80μg kanye, 2 ~ 4 izikhathi ngosuku.Uma usebenzisa, qala ngokukhipha ikepisi yegobolondo lekhava, beka igobolondo lekhava eliphambanayo emlonyeni, phendulela ibhodlela phansi, faka igobolondo lekhava emlonyeni, uqondise emphinjeni, donsa igesi ngesikhathi esifanayo, cindezela umlomo wombhobho. ku-valve, donsa uketshezi, ubambe umoya wakho isikhashana.Phinda i-snap engenhla kanye uma kunesidingo.I-aerosol: isixazululo esingu-0.025%.Ithebhulethi: 10mg/ithebhulethi.
Ubuthi obunamandla be-anticholinergic bungelashwa ngama-cholinesterase inhibitors.
Ukusabela okungalungile kwe-ipratropium bromide kufana ne-atropine, engabangela ukushaya kwenhliziyo, ikhanda elibuhlungu, isiyezi, uvalo, isicanucanu, ukuhlanza, ubuhlungu besisu, ukuthuthumela, ukungaboni kahle, umlomo owomile, ukukhwehlela, i-dysuria, ukwanda kwezimpawu zokuphefumula nokuqubuka.
I-Ipratropium bromide iyimbangi ye-muscarinic, i-bronchodilator, nosawoti we-isopropyl we-AtropineN.
I-Ipratropiumbromide ne-Formoterol zihlangene ngokwengxenye ukuze kuvikelwe amaphaphu ekuvuvukeni okungapheli futhi kwandiswe amaphaphu, kunciphise ama-neutrophils ngokuvimbela umsebenzi nge-MMP-9.I-Ipratropiumbromide(1nM) yandisa kakhulu i-calcium bromide, yanciphisa ukusakazeka phambili futhi yanda ukubopha kwe-annexin-V.Ngemuva kokwelashwa kwe-Ipratropiumbromide, i-hemolysis yanda kancane kodwa kakhulu.I-Ipratropiumbromide ibangela ukuzibulala kwamangqamuzana abomvu egazi noma i-eryptosis, ngokuyinhloko ngenxa yokuvuselela i-calcium.
I-Ipratropium i-powder dry inhalation (DPI) yayiyi-bronchodilator ephumelelayo ekuphumuleni kwamahhashi ngesilinganiso se-2400 mg / ihhashi, enomthelela omncane ku-airway caliber ephezulu ngesikhathi sokululama.Emagundaneni aphathwe nge-cadmium, i-Ipratropium yanciphisa kakhulu ukungena kwamaseli okuvuvukala kwe-parenchymal futhi yabona izilonda eziminyene zamaphaphu ezihlobene.I-Ipratropium ivikela ingxenye yamaphaphu ekuvuvukeni ngokunciphisa ukungena kwe-neutrophil.Ku-Guinea pig tracheal muscle bushelelezi, i-Ipratropium iyimbangi evimbela i-prebound muscarinic inhibitory receptor ye-lung parasympathetic nerve.I-Ipratropium nayo ikhonjiswe ukuthi iyisitha esinamandla esibophezelayo kuma-muscarinic inhibitory receptors.I-Ipratropium inciphisa izinguquko eziphezulu kumfutho wesifuba futhi ikhuphule ukuthobela okuguquguqukayo (i-Cdyn) ekuphefumuleni kwamanzi (i-Pplmax ekhulayo) kanye nokumelana namaphaphu (RL) emahhashi.