I-Peptide Synthesis:
I-Boc-Ser(Bzl)-OH isebenza njengebhlokhi yokwakha esigabeni esiqinile noma ekuhlanganiseni kwe-peptide kwesigaba sesixazululo.Ingahlanganiswa namanye ama-amino acid noma izingcezu ze-peptide ukwenza ama-peptide amade noma amaprotheni.
Iqembu le-benzyl (Bzl) livikela iqembu le-hydroxyl le-serine, livumela ukusabela okukhethiwe kwamanye amasayithi ngaphakathi kweketango le-peptide.
Iqembu le-Boc livikela iqembu le-amino, livimbela ukusabela okungafuneki ohlangothini ngesikhathi sokuhlanganiswa kwe-peptide.
Izifundo ze-Biochemical:
I-Boc-Ser(Bzl)-OH ingasetshenziswa njenge-reagent ekuhlolweni kwamakhemikhali ezinto eziphilayo ukuze kufundwe ukusebenzisana kwamaprotheni-amaprotheni, i-enzyme kinetics, nezinye izinhlelo zokusebenza zebhayoloji yamangqamuzana.
Ngokuhlanganisa lokhu kuphuma kokuphuma kwe-amino acid kuma-peptide noma amaprotheni, abacwaningi bangaphenya ukusebenza kwawo kanye nokusebenzisana namanye ama-molecule ebhayoloji.
Ukutholwa Kwezidakamizwa:
I-Boc-Ser(Bzl)-OH ingafakwa emithini ye-peptidomimetics noma ye-peptide, eklanyelwe ukulingisa imisebenzi yebhayoloji yama-peptide emvelo.
Lawa ma-peptidomimetics angase abe namandla okwelapha ezindaweni ezinjengomdlavuza, izifo ezithathelwanayo, nokuphazamiseka kwemizwa.
Iqembu le-benzyl lingasuswa ngesikhathi sokuthuthukiswa kwezidakamizwa ukuze kwembule iqembu lamahhala le-hydroxyl le-serine, elingase libe semqoka emsebenzini webhayoloji we-peptide.
Isayensi Yezinto Ezibalulekile:
I-Boc-Ser(Bzl)-OH ingasetshenziswa ekuhlanganiseni ama-polymers ahambisana ne-biocompatible kanye ne-biodegradable for tissue engineering, ukulethwa kwezidakamizwa, nezinye izinhlelo zokusebenza ze-biomedical.
Lawa ma-polymers angaklanywa ukuthi akhiphe izidakamizwa noma ama-molecule e-bioactive ngendlela elawulwayo, athuthukise ukusebenza kahle kwawo kokwelapha kanye nokunciphisa imiphumela engemihle.