isibhengezo_sekhasi

30992-29-1 Boc-L-Aib-OH

30992-29-1 Boc-L-Aib-OH

Incazelo emfushane:

Ukubukeka Impushana emhlophe
MF I-C9H17NO4
MW 203.24
Ubumsulwa 98+


Imininingwane Yomkhiqizo

Isimo sezokuthutha
Kungaba kuzinga lokushisa elijwayelekile

Ncoma indlela yokuthumela
Ngomoya Ngomhlaba Ngasolwandle

Isimo sesitoreji:
Gcina endaweni emnyama, emkhathini ongangeni, izinga lokushisa legumbi

Impilo yeshelufu
Cishe iminyaka emi-2

Ubuncane be-oda Ubuningi:
1kg (ingxoxo)

Isitifiketi:I-COA, indawo encibilikayo, i-SpecificRotation [α]D20                      

Sizothumela noma iyiphi idatha oyifunayo.Ungabona idatha ngaphambili njengereferensi.

Ngemikhiqizo eyenziwe ngokwezifiso, sithumela idatha entsha kakhulu ngemuva kokuthi iphumile.

I-D-Ls(tfa)-NCA (2)

Omqondofana

I-BOC-alpha-Methylalanine
N-BOC-2-AMINOISOBUTYRICACID;
I-N-ALPHA-T-BUTOXYCARBONYL-ALPHA-AMINOISOBUTYRICACID;
2-Methyl-2-(tert-butoxycarbonylamino)propionicacid;
I-N-(tert-Butoxycarbonyl) -2-methylalanine;
I-N-(tert-Butoxycarbonyl)-2-methyl-L-alanine

Ukupakisha kwangaphakathi

Zivame ukusetshenziselwa ukupakisha impushana.Kuya ngemfuneko yamakhasimende.Ngakho-ke, sitshele ngenkani yakho ngaphambi kokupakisha uma unezicelo ezikhethekile.

Ukupakisha kwangaphakathi 2
Ukupakisha kwangaphakathi 1
Ukupakisha kwangaphakathi 3

ukupakisha kwangaphandle

Ukupakisha kwangaphandle kunzima.Futhi kunzima ukusika nokulimaza.Ingavikela imikhiqizo yakho ngokuphelele.

Ukupakisha kwangaphandle 3
Ukupakisha kwangaphandle 2
Ukupakisha kwangaphandle 1

Izinhlelo zokusebenza

30992-29-1 I-Boc-L-Aib-OH ingaba ngomunye wabamaphakathi be-Anamorelin.

1. Ukwesekwa kokudla okunomsoco kanye nokukhuthaza ukudla (indima ye-Anamorelin)

Njengomuthi omusha wokwelapha i-cachexia yomdlavuza, i-Anamorelin ingakhuthaza iziguli ukuthi zidle izakhi eziningi ngokuvuselela isifiso sokudla.Iziguli ezinomdlavuza i-cachexia ngokuvamile zinenkinga yokungathandi ukudla, i-anorexia nokukhathala, okuholela ekwehleni kwesisindo nokungondleki kahle.I-Anamorelin ikhulisa ukudla ngokushintshanisa ukukhululwa kwamahomoni esifiso sokudla kanye nokwenza ngcono ukuqashelwa kwesiguli nokusabela kokudla.Ngokwenza ngcono ukudla okunomsoco, i-Anamorelin isiza ukuthuthukisa isimo somzimba wesiguli nokwandisa ukumelana nezifo.

2. Ukuvikelwa kwemisipha kanye nokululama kokusebenza

Iziguli ezine-cachexia zivame ukuhlotshaniswa nokulahlekelwa kwemisipha nokunciphisa ukusebenza komzimba.I-Anamorelin ivikela futhi ikhulise imisipha ye-muscle ngokuthuthukisa ukusebenza kahle kwe-protein metabolism, ikhulise ibhalansi ye-protein synthesis kanye nokuwohloka, nokunciphisa i-muscle catabolism ngenkathi ikhuthaza ukudla.Ngaphezu kwalokho, i-Anamorelin ithuthukisa ukukhathala nokuqina, isiza iziguli ezine-cachexia ukuthi ziphinde ziphinde zivuselele amandla nokusebenza.

3. Ukuthuthukiswa kwesimo somqondo kanye nezinga lempilo

I-Cancer cachexia ayithinti nje kuphela impilo yomzimba yeziguli, kodwa futhi ithinta kakhulu isimo sazo sengqondo kanye nezinga lempilo yazo.Umphumela wokwelapha we-Anamorelin awugcini nje kuphela esicini somzimba, ungase futhi uthuthukise imizwelo nemizwa yesiguli ngokuthuthukisa isimo sengqondo.Ucwaningo luye lwabonisa ukuthi iziguli ezisebenzisa i-Anamorelin zinentuthuko enkulu esimweni sengqondo, ukusebenza komphakathi, ukukhathala nokwaneliseka kokuphila.Ithuthukisa kakhulu izinga lempilo yeziguli futhi ikhulise ukuzethemba kwazo ekulweni nomdlavuza.

4. Umphumela wokwelashwa ophelele kanye nokuthuthukiswa kokuvuselela

I-Anamorelin inendima ebalulekile ekwelapheni okudidiyelwe phakathi kweziguli ezinomdlavuza ezinesifo esiyingozi.Ingahlanganiswa nezinye izidakamizwa, i-chemotherapy, i-radiotherapy nezinye izindlela zokwelapha ukwenza umphumela ophelele.Ngokuthuthukisa isimo somsoco wesiguli, isisindo semisipha kanye nesimo sengqondo, i-Anamorelin ingathuthukisa umphumela wokwelapha jikelele.Iziguli ezine-cachexia nazo zingazuza ohlelweni lokuvuselela.

imikhiqizo ehlobene

Boc-Tyr(Kodwa)-Aib-OH L-Aib-OH 2-Aib-Ome.Hcl
I-L-Aib-Oet.Hcl Cbz-Aib-Otbu-OH Boc-Aib-Ome-OH
Fmoc-Aib-OH Cbz-Aib-OH

Ukuphakama

1. Sihlinzeka ngokwezifiso imikhiqizo oyidingayo.
2. Ikhwalithi ephezulu kanye nentengo yokuncintisana inganikezwa.
3.Sithembisa inkambo ephelele yokulandelela isevisi yakho.
4. Uhlu lwemibuzo yabahlinzeki kanye nemibhalo yezobuchwepheshe inganikezwa uma isicelo emva kokuhlangabezana nenani elithile.
5. Isevisi enhle yangemuva kokuthengisa noma isiqinisekiso : Noma yimuphi umbuzo wakho uzoxazululwa ngokushesha okukhulu.
6. Thumela imikhiqizo encintisanayo futhi uyithumele emazweni angaphandle ngobuningi njalo ngonyaka.
7.Isampula yamahhala enikezwa ukuhlola ikhwalithi ngaphambi kwanoma iyiphi inkokhelo.


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