I-China 3415-08-5 L-Tyr-NCA Umkhiqizi kanye Nemboni |Jiayinglai

3415-08-5 L-Tyr-NCA

Incazelo emfushane:

Ukubukeka	Amakristalu amhlophe kuya kokumhlophe noma impushana ecwebezelayo
MF	I-C10H9NO4
MW	207.18
Ubumsulwa	98+

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Isimo sezokuthutha&indlela yokuthumela enconyiwe:
ngomoya, ngolwandle noma nge-express

Isimo sesitoreji:
umoya opholile, Gcina efrijini, ngaphansi kuka -20°C

Ubuncane be-oda Ubuningi:
Ukuxoxisana

Isitifiketi:
I-COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyatholakala

Omqondofana

I-Tyrosine, i-NCA;

I-N-Carboxy-L-tyrosine anhydride;

(4S) -4- [(4-Hydroxyphenyl)methyl]-2,5-oxazolidinedione;

L-Tyrosine N-carboxyanhydride;

(2,5-Oxazolidinedione,4-[(4-hydroxyphenyl)Methyl]-, (4S)-;

I-N-Carbonyl-L-Tyrosine Anhydride

Ukupakisha kwangaphakathi

Ngokuvamile zisetshenziselwa ukupakisha impushana.Futhi zingavimbela ukukhanya kwelanga namanzi ukuba kungabi kubi.

ukupakisha kwangaphandle

Ibhokisi eliqinile lingavikela imikhiqizo yakho ukuthi ingaphahlazeka futhi ibe manzi.

Izinhlelo zokusebenza

I-3415-08-5 L-Tyr-NCA ingenye yabamaphakathi be-Glatiramer Acetate.

I-Glatiramer Acetate iyi-ejenti ye-peptide elungiselelwe ngokwenziwa eyakhiwe ngama-amino acid amane: i-glutamic acid, i-alanine, i-tyrosine, ne-lysine.Ukusebenza kwayo okuyinhloko kusekwelapheni i-Multiple Sclerosis (MS), isifo esingelapheki, esivuvukalayo, esiqeda ukuvuvukala esithinta isimiso sezinzwa esimaphakathi.Ngokusebenzisa indlela "yokucindezelwa kwe-bypass," i-Glatiramer Acetate yenza i-immunomodulatory kanye nemiphumela yokulwa nokuvuvukala ku-MS, ikhulisa amazinga e-brain-derived neurotrophic factor (BDNF), yehlisa ukuchithwa kwegazi okubangelwa ukuvuvukala, futhi ikhuthaze ukukhula kwama-axon namashethi e-myelin.

Emhlabeni jikelele, i-Glatiramer Acetate ithole ukusetshenziswa okubanzi.Isibonelo, e-United States, idayiswa ngaphansi kwegama lomkhiqizo i-Copaxone futhi ivunyelwe yi-Food and Drug Administration (FDA) ukuze zelashwe i-Multiple Sclerosis.Emazweni aseNtshonalanga anokusabalala okukhulu kwe-MS, ukusebenza kwayo nokubekezelelana kwayo kuye kwaqashelwa kabanzi.

E-China, ngo-June 28, 2023, "I-Glatiramer Acetate Injection" yathola imvume ngokusemthethweni evela kwa-National Medical Products Administration (NMPA) yokwelapha iziguli ezikhulile ezine-Multiple Sclerosis (MS) ebuyela emuva ebuyela emuva, okuhlanganisa nesifo esihlukaniswa nomtholampilo, ukuphindisela emuva. I-MS, kanye ne-MS yesibili eqhubekayo esebenzayo.

imikhiqizo ehlobene

I-L-Gly-NCA	I-L-Ala-NCA	I-D-Ala-NCA	I-L-Val-NCA
I-D-Leu-NCA	I-DL-leu-NCA	L-Phe-NCA	I-D-Tyr-NCA
I-L-Tyr(bzl)-NCA	I-L-Glu(Obzl)-NCA	I-D-Asp(OBzl)-NCA	I-L-Ls(tfa)-NCA
L-Ls(Cbz)-NCA	I-D-Ls(Cbz)-NCA	I-Sar-NCA

Ukuphakama

1. Isevisi ye-R&D iyatholakala
2. Umkhiqizi oqinisekisiwe we-ISO, isiqinisekiso sekhwalithi
I-3.Inkambo ephelele yenkonzo yokulandelela ngesikhathi sokukhiqiza
I-4.Izindleko eziphezulu
5.Imibhalo yesitifiketi sekhwalithi enikeziwe ngokwesicelo sekhasimende ngalinye
I-6.Isevisi enhle emva kokuthengisa, ukugcina ubuhlobo obuseduze nekhasimende
7.Insiza egcwele yokusiza ukwehlisa izindleko zokuthumela
8.Isampula yamahhala enikelwe ukuhlola ikhwalithi ngaphambi kwanoma iyiphi inkokhelo
9.Isikhathi sokukhokha okuxoxiswana ngaso
10.Amakhasimende e-Assit abhekana nezindaba zaseShayina