I-China 40216-83-9 H-Hyp-Ome·HCl Umkhiqizi Nefekthri |Jiayinglai

40216-83-9 H-Hyp-Ome·HCl

Incazelo emfushane:

Ukubukeka	Impushana emhlophe
MF	I-C6H12ClNO3
MW	181.62
Ubumsulwa	98+

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Isimo sezokuthutha
Kungaba kuzinga lokushisa elijwayelekile

Ncoma indlela yokuthumela
Ngomoya Ngomhlaba Ngasolwandle

Isimo sesitoreji:
Gcina endaweni emnyama, emkhathini ongangeni, izinga lokushisa legumbi

Impilo yeshelufu
Cishe iminyaka emi-2

Ubuncane be-oda Ubuningi:
1kg (ingxoxo)

Isitifiketi:I-COA, indawo encibilikayo, i-SpecificRotation [α]_D²⁰

Sizothumela noma iyiphi idatha oyifunayo.Ungabona idatha ngaphambili njengereferensi.

Ngemikhiqizo eyenziwe ngokwezifiso, sithumela idatha entsha kakhulu ngemuva kokuthi iphumile.

Omqondofana

I-H-HYP-OMEHCL;
I-HL-HYP-OMEHCL;
I-HYDROXYPROLINE-OMEHCL;
(2S,4R)-trans-4-hydroxy-L-prolinemethylesterhydrochloride;
I-4-hydroxy-2-pyrrolidinecarboxylicacidmethylesterhydrochloride;
L-4-HYDROXYPROLINEMETHYLESTERHYDROCHLORIDE;
L-4-HYDROXYPROLINEMETHYLESTERHYDROCHLORIDESALT;
I-L-4-TRANS-HYDROXYPROLINEMETHYLESTERHYDROCHLORIDE

Ukupakisha kwangaphakathi

Zivame ukusetshenziselwa ukupakisha impushana.Kuya ngemfuneko yamakhasimende.Ngakho-ke, sitshele ngenkani yakho ngaphambi kokupakisha uma unezicelo ezikhethekile.

ukupakisha kwangaphandle

1kg kuya ku-25kg Ukupakisha kwangaphandle kunzima.Futhi kunzima ukusika nokulimaza.Ingavikela imikhiqizo yakho ngokuphelele.

Izinhlelo zokusebenza

Isebenzisa: I-H-Hyp-OMe·HCl isebenza njengesixhumanisi esingasuki se-ADC (antibody-drug conjugate) sokuhlanganiswa kwama-ADC.Ama-ADC, akhiwe i-antibody kanye ne-cytotoxin exhunywe ngesixhumi se-ADC, anika amandla ukulethwa okunembile kwama-cytotoxins ukuze aqondise amaseli, ngaleyo ndlela elapha izifo ezithile.Ukwengeza, i-H-Hyp-OMe·HCl iyisixhumanisi se-PROTAC (ukuwohloka kwamaprotheni okuqondiswe ku-chimera) esisekelwe kumaketanga e-alkyl, asetshenziswa ekuhlanganiseni ama-PROTAC.Ama-PROTAC, aqukethe ama-ligand amabili ahlukene axhunywe isixhumanisi, asebenzisa isistimu yeselula ye-ubiquitin-proteasome ukuze alulaze ngokukhetha amaprotheni aqondiwe.

Izakhiwo: I-H-Hyp-OMe·HCl iyimpushana ye-amorphous emhlophe noma ephuzi kancane encibilika kuzincibilikisi ezifana namanzi, i-methanol, ne-ethanol.Ibonisa ukuzinza okuhle kanye ne-biocompatibility, igcina umsebenzi wayo nokuzinza ngaphansi kwezimo zomzimba.

Sekukonke, i-H-Hyp-OMe·HCl idlala indima ebalulekile ekuhlanganisweni kwama-ADC nama-PROTAC njengesisebenzi esibalulekile samakhemikhali ezinto eziphilayo kanye nethuluzi lokuthuthukisa izidakamizwa.Inikeza izindlela ezintsha nezindlela zokwelapha izifo.Njengoba ucwaningo luqhubeka nobuchwepheshe buthuthuka, amathuba okusebenzisa i-H-Hyp-OMe·HCl kulindeleke ukuthi ande.

imikhiqizo ehlobene

L-Hyp-OH	HL-Hyp-Ome·HCl
I-HL-Hyp-Oet.HCl	I-L-Hyp-Obzl.Hcl
I-Boc-L-Hyp-OH	I-Boc-L-Hyp-Ome
I-Fmoc-L-Hyp-Ome	I-Boc-L-Hyp-oet
Fmoc-L-Hyp-OH	I-Fmoc-L-Hyp(tbu)-OH
Cbz-L-Hyp-OH	Cbz-L-Hyp-OMe

Ukuphakama

1. Sihlinzeka ngokwezifiso imikhiqizo oyidingayo.
2. Ikhwalithi ephezulu kanye nentengo yokuncintisana inganikezwa.
3. Sithembisa inkambo ephelele yokulandelela.
4. Uhlu lwemibuzo yabahlinzeki kanye nemibhalo yezobuchwepheshe inganikezwa uma isicelo emva kokuhlangabezana nenani elithile.
5. Isevisi enhle yangemuva kokuthengisa noma isiqinisekiso : Noma yimuphi umbuzo wakho uzoxazululwa ngokushesha okukhulu.
6. Thumela imikhiqizo encintisanayo futhi uyithumele emazweni angaphandle ngobuningi njalo ngonyaka.
7. Isampula yamahhala enikezwa ukuhlola ikhwalithi ngaphambi kwanoma iyiphi inkokhelo.

Okwedlule: 33208-99-0 L-Ala-NH2.HCl

Olandelayo: 7362-93-8 H-Asp-OBzl

Bhala umlayezo wakho lapha futhi usithumelele wona