isibhengezo_sekhasi

68858-20-8 Fmoc-L-Val-OH

68858-20-8 Fmoc-L-Val-OH

Incazelo emfushane:

Ukubukeka Impushana emhlophe ukuya kokumhlophe
MF I-C20H21NO4
MW 339.39
Ubumsulwa 98+


Imininingwane Yomkhiqizo

Isimo sezokuthutha
Kungaba kuzinga lokushisa elijwayelekile

Ncoma indlela yokuthumela
Ngomoya Ngomhlaba Ngasolwandle

Isimo sesitoreji:
Gcina endaweni emnyama, emkhathini ongangeni, izinga lokushisa legumbi

Impilo yeshelufu
Cishe iminyaka emi-2

Ubuncane be-oda Ubuningi:
1kg (ingxoxo)

Isitifiketi:I-COA, indawo encibilikayo, i-SpecificRotation [α]D20                      

Sizothumela noma iyiphi idatha oyifunayo.Ungabona idatha ngaphambili njengereferensi.

Ngemikhiqizo eyenziwe ngokwezifiso, sithumela idatha entsha kakhulu ngemuva kokuthi iphumile.

I-D-Ls(tfa)-NCA (2)

Omqondofana

FMOC-L-Valine

N-FMOC-VAL-OH

N-FMOC-L-VAL

I-N-FMOC-L-VALINE N-(9-FLUORENYLMETHOXYCARBONYL)-L-VALINE

I-N-9-FLUORENYLMETHYLOXYCARBONYL-L-VALINE

N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-VALINE

I-N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-VALINE N-ALPHA-FMOC-L-VALINE

Ukupakisha kwangaphakathi

Zivame ukusetshenziselwa ukupakisha impushana.Kuya ngemfuneko yamakhasimende.Ngakho-ke, sitshele ngenkani yakho ngaphambi kokupakisha uma unezicelo ezikhethekile.

Ukupakisha kwangaphakathi 2
Ukupakisha kwangaphakathi 1
Ukupakisha kwangaphakathi 3

ukupakisha kwangaphandle

1kg kuya ku-25kg Ukupakisha kwangaphandle kunzima.Futhi kunzima ukusika nokulimaza.Ingavikela imikhiqizo yakho ngokuphelele.

Ukupakisha kwangaphandle 3
Ukupakisha kwangaphandle 2
Ukupakisha kwangaphandle 1

Izinhlelo zokusebenza

I-68858-20-8 Fmoc-L-Val-OH ingenye ye-Abaloparatide intermediate.

Okokuqala, i-Abaloparatide yenza ukulawula umzimba futhi ikhuthaze ukwakheka kwamathambo ngokukhetha ngokukhetha isiteshi sokusayina se-PTH1 yohlobo lwe-1 receptor (PTH1R).Yandisa kakhulu ukuminyana kwamathambo futhi inciphisa ingozi yokuphuka.Ucwaningo luye lwabonisa ukuthi emadodeni ane-osteoporosis, ukwelashwa nge-Abaloparatide kuthuthukisa kakhulu futhi ngokushesha i-BMD (amathambo amaminerali) omgogodla, intamo yesifazane, ne-hip ephelele uma kuqhathaniswa ne-placebo.

Okwesibili, i-Abaloparatide ivunyelwe ukumakethwa yi-US Food and Drug Administration (FDA) yokwelashwa kwe-osteoporosis kwabesifazane abangemva kokuya esikhathini abasengozini yokuphuka noma abangazange baphendule kwamanye ama-ejenti okwelapha.Ngaphezu kwalokho, lesi sidakamizwa siphinde siboniswe ngamadoda amadala okungaboniswanga ukwelashwa kwe-testosterone esikhundleni sokunciphisa ingozi yesiguli yokuphuka kwama-vertebral nokwandisa amandla amathambo ekuqhekekeni kwe-hip nokungewona ama-hip.

Uma usebenzisa i-Abaloparatide, umthamo onconyiwe ngu-80mcg olawulwa ngaphansi kwesikhumba kanye ngosuku.Uma ukudla kwesiguli kunganele, i-calcium ne-vitamin D kufanele yengezwe.Ngaphambi kokuphatha, qiniseka ukuthi isipetu nenaliti yezidakamizwa zihlanzekile futhi ziyinyumba.

Sekukonke, i-Abaloparatide iboniswe ukuthi iyasebenza ekwelapheni i-osteoporosis futhi isetshenziswe kabanzi emisebenzini yomtholampilo.

imikhiqizo ehlobene

L-Val-OH I-D-Val-OH N-Me-D-Val-OH Pht-Val-OH
I-AC-Val-OH I-Boc-L-Val-OH I-Boc-D-Val-OH I-Boc-N-Me-Val-OH
I-Fmoc-D-Val-OH Cbz-L-Val-OH Cbz-D-Val-OH I-Cbz-Val-Val-OH

Kungani Khetha Thina

1. Mayelana ne-MOQ: Singayilungisa ngokuvumelana nemfuneko yakho.
2. Mayelana nesampula: Isampula idinga imali yesampula, okungaba yimpahla ongayilanda noma ongayikhokha kithi kusengaphambili.
3. I-Mold workshop, ingenziwa ngezifiso ngokusho kwenani lamamodeli.
4. Sinikeza isevisi engcono kakhulu.Ithimba labadayisi abanolwazi selisebenzela wena.
5. Mayelana nokushintshisana: Ngicela ungithumele i-imeyili noma ungixoxele ngesikhathi esivumelana nawe.


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