isibhengezo_sekhasi

7536-55-2 Boc-L-Asn-OH

7536-55-2 Boc-L-Asn-OH

Incazelo emfushane:

Ukubukeka Impushana emhlophe
MF I-C9H16N2O5
MW 232.23
Ubumsulwa 98+


Imininingwane Yomkhiqizo

Isimo sezokuthutha
Kungaba kuzinga lokushisa elijwayelekile

Ncoma indlela yokuthumela
Ngomoya Ngomhlaba Ngasolwandle

Isimo sesitoreji:
Gcina endaweni emnyama, emkhathini ongangeni, izinga lokushisa legumbi

Impilo yeshelufu
Cishe iminyaka emi-2

Ubuncane be-oda Ubuningi:
1kg (ingxoxo)

Isitifiketi:I-COA, indawo encibilikayo, i-SpecificRotation [α]D20                      

Sizothumela noma iyiphi idatha oyifunayo.Ungabona idatha ngaphambili njengereferensi.

Ngemikhiqizo eyenziwe ngokwezifiso, sithumela idatha entsha kakhulu ngemuva kokuthi iphumile.

I-D-Ls(tfa)-NCA (2)

Omqondofana

T-BUTYLOXYCARBONYL-L-ASPARAGINE;
I-TBOC-L-ASPARAGINE;
I-N-TERT-BUTOXYCARBONYL-L-ASPARAGINE;
I-NT-BUTOXYCARBONYL-L-ASPARAGINE;
I-NT-BOC-L-ASPARAGINE;
I-N2--[(1,1-Dimethylethoxy)carbonyl]-L-asparagine;
I-NALPHA-BOC-L-ASPARAGINE;
I-N-ALPHA-T-BOC-L-ASPARAGINE

Ukupakisha kwangaphakathi

Zivame ukusetshenziselwa ukupakisha impushana.Kuya ngemfuneko yamakhasimende.Iphakheji yesibili yokuqala ibonakala kancane, kodwa asikho isidingo sokukhathazeka ngalokho.Ngoba sizoba nokupakisha kwangaphandle.

Ukupakisha kwangaphakathi 2
Ukupakisha kwangaphakathi 1
Ukupakisha kwangaphakathi 3

ukupakisha kwangaphandle

Ukupakisha kwangaphandle kunzima.Futhi kunzima ukusika nokulimaza.Uma udinga noma iyiphi idokhumentari, sicela usazise kusenesikhathi.Sizowafaka kuwo.Noma ukuvula imikhiqizo epakishiwe kungase kuthinte ukubukeka kwayo kwangaphandle.

Ukupakisha kwangaphandle 3
Ukupakisha kwangaphandle 2
Ukupakisha kwangaphandle 1

Izinhlelo zokusebenza

I-Boc-L-Asn-OH, eyaziwa nangokuthi i-BOC-L-Asparagine, iwukuphuma okubalulekile kwe-amino acid nezinhlelo zokusebenza ezihlukahlukene.

Okokuqala, i-Boc-L-Asn-OH ithola ukusetshenziswa okusabalele ku-biochemistry nokutholwa kwezidakamizwa.Isebenza njengengxenye eyinhloko ku-peptide synthesis, ivumela ukwakhiwa kwamaketanga e-peptide ngemisebenzi ethile yebhayoloji.Ngenxa yezakhiwo zayo zamakhemikhali eziyingqayizivele, i-Boc-L-Asn-OH ingasabela namanye ama-amino acid noma izinhlanganisela, okuholela ekukhiqizeni izidakamizwa zenoveli noma ama-molecule e-bioactive anemisebenzi ehlukile.

Okwesibili, i-Boc-L-Asn-OH nayo inezinhlelo zokusebenza ku-biotechnology kanye ne-molecular biology.Ingasebenza njenge-amino acid evikela i-monomer, ivikela amaqembu asebenzayo kwamanye ama-amino acid noma amaketanga e-peptide ekuphenduleni kwamakhemikhali okungafuneki ngesikhathi sokuhlanganiswa noma ukuhlanzwa.Ukwengeza, i-Boc-L-Asn-OH ingasetshenziselwa ukuguqulwa kwesayithi elithile kubunjiniyela bamaprotheni, ukuguqula ukwakheka nokusebenza kwamaprotheni.

Ngaphezu kwalokho, ngokuya ngamasu okukhiqiza, i-Boc-L-Asn-OH ingahlanganiswa ngokusabela kwamakhemikhali okuthile.Ngokujwayelekile, ilungiswa kusetshenziswa i-tert-butoxycarbonyl chloride (noma i-azide) ne-L-asparagine njengezinto zokuqala.Ukusabela kwe-acylation kulandelwa yi-acidification kusetshenziswa i-citric acid bese ihlanzwa ngokuvuselela kabusha.Le nqubo yokukhiqiza inika amandla ukulungiswa kwesilinganiso esikhulu se-Boc-L-Asn-OH, ukuhlangabezana nezidingo zezicelo zayo ezihlukahlukene.

imikhiqizo ehlobene

L-Asn.H2O I-D-Asn.H2O
D-Asn L-Asn(Trt)-OH
I-Boc-L-Asn-Onp I-Boc-L-Asn-OH
I-Boc-D-Asn I-Boc-L-Asn-Oet
I-Boc-L-Asn-Obzl Fmoc-L-Asn-OH
I-Fmoc-D-Asn(Trt)-OH I-Fmoc-L-Asn(Trt)-OH
Cbz-L-Asn-OH I-Cbz-L-Asn(Trt)-OH

Ukuphakama

1. Sihlinzeka ngokwezifiso imikhiqizo oyidingayo.
2. Ikhwalithi ephezulu kanye nentengo yokuncintisana inganikezwa.
3.Sithembisa inkambo ephelele yokulandelela isevisi yakho.
4. Uhlu lwemibuzo yabahlinzeki kanye nemibhalo yezobuchwepheshe inganikezwa uma isicelo emva kokuhlangabezana nenani elithile.
5. Isevisi enhle yangemuva kokuthengisa noma isiqinisekiso : Noma yimuphi umbuzo wakho uzoxazululwa ngokushesha okukhulu.
6. Thumela imikhiqizo encintisanayo futhi uyithumele emazweni angaphandle ngobuningi njalo ngonyaka.
7.Isampula yamahhala enikezwa ukuhlola ikhwalithi ngaphambi kwanoma iyiphi inkokhelo.


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