isibhengezo_sekhasi

84758-55-4 Boc-Aib-Ome

84758-55-4 Boc-Aib-Ome

Incazelo emfushane:

Ukubukeka Impushana emhlophe
MF I-C10H19NO4
MW 217.26
Ubumsulwa 98+


Imininingwane Yomkhiqizo

Isimo sezokuthutha
Kungaba kuzinga lokushisa elijwayelekile

Ncoma indlela yokuthumela
Ngomoya Ngomhlaba Ngasolwandle

Isimo sesitoreji:
Gcina endaweni emnyama, emkhathini ongangeni, izinga lokushisa legumbi

Impilo yeshelufu
Cishe iminyaka emi-2

Ubuncane be-oda Ubuningi:
1kg (ingxoxo)

Isitifiketi:I-COA, indawo encibilikayo, i-SpecificRotation [α]D20                      

Sizothumela noma iyiphi idatha oyifunayo.Ungabona idatha ngaphambili njengereferensi.

Ngemikhiqizo eyenziwe ngokwezifiso, sithumela idatha entsha kakhulu ngemuva kokuthi iphumile.

I-D-Ls(tfa)-NCA (2)

Omqondofana

i-methyl 2-tert-butoxycarbonylamino-2-methylpropanoate;
i-methyl 2-aminobutoxycarbonyl-2-methylpropanoate;
I-N-tert-butoxycarbonyl-α-methylalanine methyl ester;
i-methyl 2-(tert-butoxycarbonylamino) -2-methylpropanoate;
N-(tert-butoxycarbonyl)-α-methylalanine methyl ester;
i-methyl N-(tert-butoxycarbonyl) -2-methyl-alaninate;

Ukupakisha kwangaphakathi

Zivame ukusetshenziselwa ukupakisha impushana.Kuya ngemfuneko yamakhasimende.Sizoqinisekisa iphakheji nawe ngaphambi nangemva kokuphuma kwemikhiqizo futhi sikuthumelele izithombe.

Ukupakisha kwangaphakathi 2
Ukupakisha kwangaphakathi 1
Ukupakisha kwangaphakathi 3

ukupakisha kwangaphandle

Ukupakisha kwangaphandle kunzima.Futhi kunzima ukusika nokulimaza.Ingavikela imikhiqizo yakho ngokuphelele.

Ukupakisha kwangaphandle 3
Ukupakisha kwangaphandle 2
Ukupakisha kwangaphandle 1

Izinhlelo zokusebenza

I-Peptide Synthesis: I-Boc-Aib-Ome isebenza njengebhlokhi yokwakha ekuhlanganiseni kwe-peptide yesigaba esiqinile.Ingafakwa kumaketanga e-peptide ukwethula ukulandelana okuqondile kwe-amino acid.Iqembu lokuvikela le-Boc livumela ukusabela okulawulwayo kokuhlangana, okuqinisekisa ukuhlangana okunembile kwama-peptide.Uma ukuhlanganiswa kwe-peptide sekuqediwe, iqembu le-Boc lingasuswa ukuze liveze ukusebenza kwe-amino ukuze kulungiswe noma kuhlanganiswe.

Ukutholwa Kwezidakamizwa: I-Boc-Aib-Ome ithola izinhlelo zokusebenza ekwakhiweni kwezidakamizwa ezinoveli ezisuselwa ku-peptide.Ngokuhlanganisa lokhu okuphuma kokuphuma kwe-amino acid ekulandeleni kwe-peptide, abacwaningi bangahlola ama-agent okwelapha angaba khona ngemisebenzi eyingqayizivele yebhayoloji.Iqembu elivikelayo le-Boc linikeza ukuzinza ngesikhathi senqubo yokwenziwa, okuvumela ukulungiswa kwama-peptide conjugates anezakhiwo ezithuthukisiwe ze-pharmacokinetic.

I-Bioconjugation: I-Boc-Aib-Ome ingasetshenziswa ekuphenduleni kwe-bioconjugation ukuxhumanisa ama-peptide noma amaprotheni kwamanye ama-molecule e-biological.Ukusebenza kwe-methyl ester kuvumela ukunamathiselwa okuhlangene kuma-molecule ahlukahlukene, njengamasosha omzimba, ama-carbohydrates, noma amanye ama-peptide.Lokhu kuvumela ukudalwa kwamasistimu okulethwa okuhlosiwe, ama-biosensors, noma amanye ama-bioactive conjugates anokusebenza okuthuthukisiwe.

Izifundo ze-Biochemical: I-Boc-Aib-Ome ingasetshenziswa njengethuluzi ocwaningweni lwamakhemikhali ezinto eziphilayo ukuze kuphenywe ukusebenzisana kwamaprotheni namaprotheni, i-enzyme kinetics, noma ukucaciswa kwe-substrate.Ngokuhlanganisa lokhu kuphuma kokuphuma kwe-amino acid kuma-peptide asetshenziswa njengama-probes noma ama-inhibitors, abacwaningi bangathola ukuqonda mayelana nezinqubo zezinqubo zebhayoloji.

imikhiqizo ehlobene

Ayib Boc-Tyr (Kodwa).Aib 2-Aib-Ome.Hcl
2-Aib-Ome.Hcl 2-Aib-Ome.Hcl I-L-Aib-Oet.Hcl
Boc-Aib-OH Boc-Aib-OH Boc-Aib-OH
Boc-aib-Ome Fmoc-Aib-OH Fmoc-Aib-OH
Fmoc-Aib-OH Fmoc-Aib-OH Fmoc-Aib-OH
Fmoc-Aib-OH Z-Aib-OH Cbz-Aib-Otbu

Ukuphakama

1. Sihlinzeka ngokwezifiso imikhiqizo oyidingayo.
2. Ikhwalithi ephezulu kanye nentengo yokuncintisana inganikezwa.
3.Sithembisa inkambo ephelele yokulandelela isevisi yakho.
4. Uhlu lwemibuzo yabahlinzeki kanye nemibhalo yezobuchwepheshe inganikezwa uma isicelo emva kokuhlangabezana nenani elithile.
5. Isevisi enhle yangemuva kokuthengisa noma isiqinisekiso : Noma yimuphi umbuzo wakho uzoxazululwa ngokushesha okukhulu.
6. Thumela imikhiqizo encintisanayo futhi uyithumele emazweni angaphandle ngobuningi njalo ngonyaka.
7.Isampula yamahhala enikezwa ukuhlola ikhwalithi ngaphambi kwanoma iyiphi inkokhelo.


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