103898-11-9 Tert-Butyl N,N-Bis(2-Hydroxyethyl)Carbamate

Ukutholwa Kwezidakamizwa: I-Tert-Butyl N,N-Bis(2-Hydroxyethyl)I-Carbamate ivamise ukusetshenziswa njengeqembu elivikelayo ekutholakaleni kwezidakamizwa.Ihlangana namaqembu asebenzayo njengama-hydroxyls nama-amine kuma-molecule ezidakamizwa, enze okuphuma kokuphuma okuvikelekile kwe-tert-butoxycarbonyl (Boc) okuzinzile.Lokhu kuvikela kuvumela ukuhlanganiswa okuzinzile nokuhlanzwa, futhi iqembu le-Boc lingasuswa ngaphansi kwezimo ezifanele ukuze liveze iqembu langempela elisebenzayo ukuze uthole ukusabela okwengeziwe noma izifundo zebhayoloji.Ngakho-ke, inezinhlelo zokusebenza ezingase zibe khona ekuhlanganiseni izidakamizwa, ukuguqulwa kwezidakamizwa, nokukhishwa kwezidakamizwa okulawulwayo.

I-Peptide Synthesis: I-Tert-Butyl N,N-Bis(2-Hydroxyethyl)I-Carbamate iphinde ithole ukusetshenziswa njengesihlanganisi ekuhlanganiseni kwe-peptide.Ingasabela neqembu le-carboxyl lama-amino acid, yakhe izibopho eziqinile ze-amide ukuze ixhume ama-amino acid amabili noma ngaphezulu, idale amaketanga e-peptide ngokulandelana nezakhiwo ezithile.Lesi sixhumanisi sisetshenziswa kakhulu ku-solid-phase peptide synthesis, liquid-phase peptide synthesis, nezinye izindlela.

Ucwaningo lwe-Biochemical: Ngenxa yemvelo yayo engaboli, i-Tert-Butyl N,N-Bis(2-Hydroxyethyl)Carbamate nayo isetshenziswa njengethuluzi ocwaningweni lwamakhemikhali ezinto eziphilayo.Isibonelo, ingasetshenziswa njengesixhumi ekuhlanganiseni ama-antibody-drug conjugates (ADCs), ukuxhuma izidakamizwa kuma-antibody ukuze zilethwe futhi zikhishwe.Ukwengeza, ingasetshenziswa ukutadisha ukusebenzisana kwamaprotheni-amaprotheni kanye ne-protein-ligand, kanye nokwenza kwasendaweni kwamaprotheni nokusebenza ngaphakathi kwamaseli.