isibhengezo_sekhasi

15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH

15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH Isithombe Esifakiwe
  • 15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH
  • 15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH
  • 15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH

15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH

Incazelo emfushane:

Ukubukeka Amakristalu amhlophe kuya kokumhlophe noma impushana ecwebezelayo.
MF I-C16H23NO5
MW 309.36
Ubumsulwa 98+


Imininingwane Yomkhiqizo

Isimo sezokuthutha&indlela yokuthumela enconyiwe:
ngomoya, ngolwandle noma nge-express

Isimo sesitoreji:
Gcina endaweni emnyama, evalwe endaweni eyomile, Emazingeni Okushisa Egumbi

Ubuncane be-oda Ubuningi:
Ukuxoxisana

Isitifiketi:
I-COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyatholakala

I-D-Ls(tfa)-NCA (2)

Omqondofana

I-Boc-O-Benzyl-L-threonine;
BOC-THR-OH;
I-BOC-THR(BZL)-OH;
I-Butoxacarbonyl benzylthreonine;
I-NT-boc-O-benzyl-L-threonine*crystalline;
I-O-benzyl-N-tert-butoxycarbonyl-L-threonine;
N-ALPHA-T-BUTYLOXYCARBONYL-O-BENZYL-L-THREONINE;
I-NALPHA-tert-Butoxycarbonyl-O-benzyl-L-threonine

Ukupakisha kwangaphakathi

Ngokuvamile zisetshenziselwa ukupakisha impushana.Futhi zingavimbela ukukhanya kwelanga namanzi ukuba kungabi kubi.

Ukupakisha kwangaphakathi 2
Ukupakisha kwangaphakathi 1
Ukupakisha kwangaphakathi 3

ukupakisha kwangaphandle

Ibhokisi eliqinile lingavikela imikhiqizo yakho ukuthi ingaphahlazeka futhi ibe manzi.

Ukupakisha kwangaphandle 3
Ukupakisha kwangaphandle 2
Ukupakisha kwangaphandle 1

Izinhlelo zokusebenza

I-crystalline powder emhlophe;Ayincibiliki emanzini naku-petroleum ether, encibilika ku-ethyl acetate ne-methanol;mp yi-115-116 ℃;Ukujikeleza okuqondile [α]20D+15.8°(0.5-2.0 mg/ml, i-methanol).
Isetshenziselwa ukuhlanganiswa kwe-polypeptide, njenge-monomer yokuvikela i-amino acid.
I-O-benzyl-l-threonine yamiswa kusixazululo se-dioxane futhi yafakwa i-acylated nge-tert-butylcarbonyl azide ukuze kutholwe umkhiqizo ongahluziwe, okhishwe nge-ethyl acetate ku-pH engu-9-10 yase iphinde yahlanganiswa.
Ingxenye esebenzayo ye-thymic oietin Ⅱ ye-thymus secretions.I-Thymoietin II iyinhlanganisela ye-polypeptide eyodwa ehlukanisiwe ne-thymus hormone.Yakhiwe ngama-amino acid angama-49, futhi ucezu lweketango le-peptide elakhiwe ama-amino acid ayi-5 linemisebenzi efanayo yezemvelo njenge-thymoietin II.Ngakho-ke, lesi siqeshana se-pentapeptide sibizwa ngokuthi i-thymus pentapeptide.I-white friza-yomiswa isisindo esixekethile noma impushana.
Enye yezindima ze-thymus pentapeptide ukunxenxa ukuhlukaniswa kwamaseli e-T.Ingakwazi ukukhetha ngokukhetha ukuguqulwa kwamaseli e-Thy-1- prothorax abe amaseli e-Thy-1+ T.Ukuhlukaniswa kwamaseli e-T kulamula ngokwanda kwamazinga e-cAMP e-intracellular.Omunye umsebenzi oyisisekelo we-thymus pentapeptides uwukubopha kuma-receptors athile egazi legazi le-T cell avuthiwe, ukwandisa izinga le-cAMP ye-intracellular, futhi ngaleyo ndlela kubangele uchungechunge lokusabela kwe-intracellular, okubuye kube isisekelo somsebenzi wayo wokuzivikela komzimba.Esimweni esijwayelekile somzimba, i-thymus pentapeptide ibonise umphumela wokuvuselela amasosha omzimba, ongakhuphula kakhulu izinga lokwakheka kwe-E rosette kanye nezinga lokuguqulwa kwama-splenic lymphocytes, kuthuthukise izigaba ezihlukene zokuphendula komzimba okuyisisekelo noma kwesibili, futhi kwandise inani lohlobo lwe-IgM kanye ne-IgG noma Uhlobo lwe-IgA lwama-antibody akha amaseli.I-Thymus pentapeptide ingabuye ithuthukise ukusebenza kwe-phagocytosis yama-macrophage, ikhulise umsebenzi we-enzyme kanye ne-phagocytosis yama-polymorphonuclear neutrophils, ikhulise okuqukethwe kwe-antibody ejikelezayo, futhi ithuthukise ukusebenza komzimba kwamangqamuzana abomvu egazi.I-Thymus pentapeptide ingenza kusebenze amaseli e-CD4 nama-CD8 positive, ukuze amaseli athile e-Tc akwazi ukugcina impilo ende, kodwa futhi akwazi ukwenza amaseli e-T asebenze futhi enze umsebenzi wamaseli e-Ts.Imiphumela elwa namagciwane kanye neyokwelapha ye-thymus pentapeptide ihlobene nokuthuthukiswa kwayo komsebenzi wamaseli e-TC.Inani elifanele le-thymus pentapeptide lingakhuphula kakhulu ukukhiqizwa kwe-interferon ekuvikelekeni kwe-anti-infection.Ukunxenxa kanye nokukhuthaza ukuhlukaniswa nokuvuthwa kwama-T cell;I-CD4/CD8 ijwayele ukuba yinto evamile ngokulawula ingxenye ye-T lymphocyte subsets;Thuthukisa umsebenzi we-phagocytosis wama-macrophages;Thuthukisa ukusebenza kokuzivikela kwamangqamuzana egazi abomvu;Ukwandisa umsebenzi wamangqamuzana abulalayo emvelo;Khulisa izinga lokukhiqizwa kwe-interleukin-2 kanye nenkulumo ye-receptor;Thuthukisa ukukhiqizwa kwe-γ interferon kumaseli wegazi we-mononuclear wegazi;Thuthukisa umsebenzi we-SOD ku-serum.
Ingasetshenziswa ezigulini zesimila esiyingozi ezinokukhubazeka komsebenzi wokuzivikela komzimba ngemva kwe-radiotherapy kanye ne-chemotherapy.Ukwelashwa kwe-hepatitis B;Ukuhlinzwa okukhulu kanye nezifo ezinzima;izifo ezizimele ezifana ne-rheumatoid arthritis, lupus erythematosus;Isifo sikashukela sohlobo II, isifo sokunqamuka kokuya esikhathini;Umuntu onomzimba obuthakathaka.

imikhiqizo ehlobene

I-Fmoc-L-Thr(tBu)-Phe-OH I-Boc-D-Thr-OH
HL-Thr-OH I-Boc-D-Thr(mina)-OH
I-DL-Thr I-Boc-D-Thr(Bzl)-OH
I-HL-allo-Thr-OH Cbz-Thr-OH
I-L-Thr(bzl) I-Cbz-Thr-Obzl
I-HL-Thr(tBu)-OH I-ZL-Thr-ome
L-Thr(mina) Cbz-D-Thr-OH
Thr-Otbu.hcl I-Cbz-L-Thr(tBu)-OH
L-Thr(bzl).HCl I-Cbz-L-Thr(bzl)-OH
L-Thr(mina).Hcl I-Cbz-L-Thr(tBu)-OH DCHA
I-L-Thr-Obzl.HCl Fmoc-L-Thr-OH
I-HL-Thr-OMe.HCl fmoc-L-Thr-OtBu
I-L-Thr-Oet.Hcl I-Fmoc-L-Thr-Obzl
L-Allo-Thr-Ome.Hcl Fmoc-L-Allo-Thr-OH
I-HL-Thr-OBzl·oxalate I-Fmoc-Thr(tBu)-OH
I-D-Thr(bzl).HCl I-Fmoc-L-Thr(bzl)-OH
I-D-Thr-Oet.Hcl Fmoc-D-Thr-OH
I-D-Thr-Obzl.HCl I-Fmoc-D-Thr(bzl)-OH
I-D-Thr-Ome.HCl I-Fmoc-D-Thr(tBu)-OH
I-DL-Thr-Ome.HCl I-Fmoc-L-Thr(tBu)-Ser-OH
I-Boc-L-Thr-OtBu I-Boc-n-me-l-thr(bzl).CHA
I-Boc-L-Thr-OH I-Fmoc-N-Me-L-Thr(bzl)-OH
I-Boc-L-allo-Thr-OH I-Fmoc-L-Thr(tBu)-Gly-OH
I-Boc-Thr-OMe (2S,3S)-2-Amino-3-methoxybutanoic acid/L-AlloThr(Me)
I-Boc-Thr-Obzl (2S,3S)-2-Amino-3-methoxybutanoic acid/BOC-AlloThr(Me)
I-Boc-L-Thr(tBu)-OH I-HL-Thr(Bzl)-OBzl.oxalate
I-Boc-L-Thr(Bzl)-OH I-Boc-D-Thr-Ome
I-Boc-L-Thr(mina)-OH

Ukuphakama

1. Isevisi ye-R&D iyatholakala
2. Umkhiqizi oqinisekisiwe we-ISO, isiqinisekiso sekhwalithi
I-3.Inkambo ephelele yenkonzo yokulandelela ngesikhathi sokukhiqiza
I-4.Izindleko eziphezulu
5.Imibhalo yesitifiketi sekhwalithi enikeziwe ngokwesicelo sekhasimende ngalinye
I-6.Isevisi enhle emva kokuthengisa, ukugcina ubuhlobo obuseduze nekhasimende
7.Insiza egcwele yokusiza ukwehlisa izindleko zokuthumela
8.Isampula yamahhala enikelwe ukuhlola ikhwalithi ngaphambi kwanoma iyiphi inkokhelo
9.Isikhathi sokukhokha okuxoxiswana ngaso
10.Amakhasimende e-Assit abhekana nezindaba zaseShayina

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