I-China 166108-71-0 Fmoc-AEEA-OH Umkhiqizi kanye Nemboni |Jiayinglai

166108-71-0 Fmoc-AEEA-OH

Incazelo emfushane:

Ukubukeka	Impushana emhlophe ukuya kokumhlophe
MF	I-C21H23NO6
MW	385.41
Ubumsulwa	98+

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Isimo sezokuthutha
Kungaba kuzinga lokushisa elijwayelekile

Ncoma indlela yokuthumela
Ngomoya Ngomhlaba Ngasolwandle

Isimo sesitoreji:
Gcina endaweni emnyama, emkhathini ongangeni, izinga lokushisa legumbi

impilo yeshelufu
Cishe iminyaka emi-2

Ubuncane be-oda Ubuningi:
1kg (ingxoxo)

Isitifiketi:I-COA, indawo encibilikayo, i-SpecificRotation [α]_D²⁰

Sizothumela noma iyiphi idatha oyifunayo.Ungabona idatha ngaphambili njengereferensi.

Ngemikhiqizo eyenziwe ngokwezifiso, sithumela idatha entsha kakhulu ngemuva kokuthi iphumile.

Omqondofana

[2--[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid

I-Fmoc-8-amino-3,6-dioxaoctanoic acid, i-Fmoc-AEEA

I-Fmoc-PEG2-acetic acid

{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid≥ 99% (HPLC)

I-Fmoc-NH-(PEG)-COOH (ama-athomu angu-9) Novabiochem

1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid

9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID

8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID

8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID

Ukupakisha kwangaphakathi

Zivame ukusetshenziselwa ukupakisha impushana.Kuya ngemfuneko yamakhasimende.Ngakho-ke, sitshele ngenkani yakho ngaphambi kokupakisha uma unezicelo ezikhethekile.

ukupakisha kwangaphandle

1kg kuya ku-25kg Ukupakisha kwangaphandle kunzima.Futhi kunzima ukusika nokulimaza.Ingavikela imikhiqizo yakho ngokuphelele.

Izinhlelo zokusebenza

166108-71-0 I-Fmoc-AEEA-OH isixhumanisi se-ADC esihlazekayo esisetshenziswa ekuhlanganiseni ama-antibody-drug conjugates (ADCs).I-Fmoc-8-amino-3,6-dioxaoctanoic acid futhi iyisixhumanisi se-PROTAC esisekelwe ku-PEG esingasetshenziswa ekuhlanganiseni ama-PROTAC.

166108-71-0 I-Fmoc-AEEA-OH futhi ingaba enye ye-semaglutide Intermediates.

Umphumela oyinhloko we-semaglutide ukwelapha uhlobo lwesifo sikashukela sohlobo 2 ngokwehlisa amazinga kashukela egazini.Ilinganisa ihomoni efana ne-insulin efana ne-peptide-1, evuselela ukukhiqizwa kwe-insulin futhi ivimbele ukukhululwa kweglucagon, ngaleyo ndlela yehlise amazinga kashukela egazini.I-Semaglutide ayifaki engcupheni ye-hypoglycemia eyenzeka uma iqhathaniswa nokwelashwa kwe-insulin evamile ngoba indlela yayo yokusebenza iyinkimbinkimbi futhi inembe kakhulu.Ngokulungisa ibhalansi ye-insulin ne-glucagon, i-somalutide ingasiza abantu abanesifo sikashukela sohlobo 2 ukulawula kangcono amazinga kashukela egazini.

Ngaphezu kokunciphisa amazinga kashukela egazini, i-semaglutide inganciphisa nesisindo somzimba.Lokhu kungenxa yomphumela wayo wokucindezela ukudla.I-semaglutide ivuselela umsebenzi wesikhungo se-satiety ku-hypothalamus, okunciphisa ukudla.Inzuzo eyinhloko ye-semaglutide phezu kwezinye izidakamizwa zokulahlekelwa isisindo ukuthi ilahlekelwa isisindo ngenkathi ithuthukisa ukumelana ne-insulin nokulawula ushukela wegazi.Lokhu kwenza kube inketho yokwelashwa efiseleka kakhulu ezigulini ezinesifo sikashukela esinokukhuluphala ngokweqile.

Ukwengeza, i-semaglutide ithuthukisa umsebenzi we-pancreatic futhi inciphisa izimpendulo zokuvuvukala kumaseli e-pancreatic islet.Ivikela amangqamuzana e-islet ekulimaleni okwengeziwe okubangelwa isifo sikashukela futhi ikhuthaza ukuvuselelwa kwama-islet cell.Lokhu kubaluleke kakhulu kubantu abanesifo sikashukela sohlobo 2, njengoba ukulimala kwe-islet cell kakhulu kungaholela ekuhlulekeni kwe-islet.

Sekukonke, i-semaglutide iwumuthi osebenza kahle kakhulu futhi ophephile wokwelashwa kwesifo sikashukela sohlobo 2.Isiza iziguli ukulawula kangcono isifo sikashukela futhi zinciphise izinkinga ngokunciphisa amazinga kashukela egazini, ukunciphisa isisindo somzimba, ukuthuthukisa ukusebenza kwe-islet, nokuvikela amaseli e-islet.Ucwaningo lwesikhathi esizayo luzoqhubeka nokuhlola amandla e-somatostatin ekwelapheni ezinye izifo, njenge-NAFLD nokukhuluphala.

imikhiqizo ehlobene

Fmoc-AEEA-AEEA-OH

Fmoc-L-Ls(dde)-OH

I-DDE-Ls(Fmoc)-OH

Kungani Khetha Thina

1. Mayelana ne-MOQ: Singayilungisa ngokuvumelana nemfuneko yakho.
2. Mayelana nesampula: Isampula idinga imali yesampula, okungaba yimpahla ongayilanda noma ongayikhokha kithi kusengaphambili.
3. I-Mold workshop, ingenziwa ngezifiso ngokusho kwenani lamamodeli.
4. Sinikeza isevisi engcono kakhulu.Ithimba labadayisi abanolwazi selisebenzela wena.
5. Mayelana nokushintshisana: Ngicela ungithumele i-imeyili noma ungixoxele ngesikhathi esivumelana nawe.

Okwedlule: 68858-20-8 Fmoc-L-Val-OH

Olandelayo: 15962-47-7 Ac-L-Ala-NH2

Bhala umyalezo wakho lapha futhi usithumelele wona