isibhengezo_sekhasi

2899-07-2 ZN-Me-L-Phe-OH

2899-07-2 ZN-Me-L-Phe-OH

Incazelo emfushane:

Ukubukeka Impushana emhlophe ukuya kokumhlophe
MF I-C18H19NO4
MW 313.35
Ubumsulwa 98+


Imininingwane Yomkhiqizo

Isimo sezokuthutha
Kungaba kuzinga lokushisa elijwayelekile

Ncoma indlela yokuthumela
Ngomoya Ngomhlaba Ngasolwandle

Isimo sesitoreji:
Gcina endaweni emnyama, emkhathini ongangeni, izinga lokushisa legumbi

Impilo yeshelufu
Cishe iminyaka emi-2

Ubuncane be-oda Ubuningi:
1kg (ingxoxo)

Isitifiketi:I-COA, indawo encibilikayo, i-SpecificRotation [α]D20                      

Sizothumela noma iyiphi idatha oyifunayo.Ungabona idatha ngaphambili njengereferensi.

Ngemikhiqizo eyenziwe ngokwezifiso, sithumela idatha entsha kakhulu ngemuva kokuthi iphumile.

I-D-Ls(tfa)-NCA (2)

Omqondofana

N-ALPHA-CARBOBENZOXY-N-ALPHA-METHYL-L-PHENYLALANINE;

N-CBZ-N-METHYL-L-PHENYLALANINE;

ZN-METHYL-L-PHENYLALANINE;

Z-MEPHE-OH;

ZN-ME-PHENYLALANINE;

ZN-ME-PHE-OH;

CBZ-N-ME-PHE-OH;

I-CBZ-N-METHYLPHENYLALANINE

Ukupakisha kwangaphakathi

Zivame ukusetshenziselwa ukupakisha impushana.Kuya ngemfuneko yamakhasimende.Ngakho-ke, sitshele ngenkani yakho ngaphambi kokupakisha uma unezicelo ezikhethekile.

Ukupakisha kwangaphakathi 2
Ukupakisha kwangaphakathi 1
Ukupakisha kwangaphakathi 3

ukupakisha kwangaphandle

1kg kuya ku-25kg Ukupakisha kwangaphandle kunzima.Futhi kunzima ukusika nokulimaza.Ingavikela imikhiqizo yakho ngokuphelele.

Ukupakisha kwangaphandle 3
Ukupakisha kwangaphandle 2
Ukupakisha kwangaphandle 1

Izinhlelo zokusebenza

I-Peptide Synthesis: I-ZN-Me-L-Phe-OH idlala indima ebalulekile ekuhlanganiseni kwe-peptide yesigaba esiqinile.Ukuvikelwa kwe-benzyloxycarbonyl (Z) ku-N-terminus kanye nokuvikelwa kwe-N-methyl kuchungechunge oluseceleni kunikeza ukukhetha nokuzinza phakathi nenqubo yokwelulwa kwe-peptide.Lokhu kuvumela ukuxhunywa kwesinyathelo ngesinyathelo nangokuhlelekile kwama-amino acid ekusekelweni okuqinile, okuvumela ukuhlanganiswa kwama-peptide ngokulandelana kanye nezakhiwo ezithile.

Ukutholwa Kwezidakamizwa: I-ZN-Me-L-Phe-OH ingasebenza njengengxenye yemizamo yokuthola izidakamizwa.Ngenxa yesakhiwo sayo samakhemikhali esiyingqayizivele, ingafakwa kumakhandidethi ezidakamizwa ukuze kuthuthukiswe umsebenzi wabo, ukuzinza, noma izakhiwo ze-pharmacokinetic.Ukwengeza, ingasetshenziswa ukuphenya izindlela zokusebenzisana phakathi kwezidakamizwa nama-molecule ebhayoloji.

Ubunjiniyela bamaprotheni: Kubunjiniyela bamaprotheni, i-ZN-Me-L-Phe-OH ingaqashwa ukuze kulungiswe noma kunjiniyela ukwakheka nokusebenza kwamaphrotheni.Ngokwethula le nhlanganisela ezindaweni ezithile ngaphakathi kwephrotheni, kungenzeka ukuguqula ukuzinza kwephrotheni, umsebenzi, ukuhlobana, noma ezinye izici ze-biophysical, okuholela ekudalweni kwamaprotheni anoveli anemisebenzi noma izici ezifiselekayo.

Ucwaningo lwe-Biochemical: I-ZN-Me-L-Phe-OH ingasebenza njengethuluzi elibalulekile ocwaningweni lwamakhemikhali ezinto eziphilayo.Ukwakheka kwayo kwamakhemikhali athile kanye nokusebenza kabusha kuyivumela ukuthi isetshenziswe ekutadisheni ukwakheka nokusebenza kwama-molecule ebhayoloji njengama-enzyme, ama-receptors, noma amaprotheni.Ngokusebenzelana namanye ama-molecule noma izinhlanganisela, ingaveza izindlela zokusebenzisana nezindlela zokusabela ngaphakathi kwezinhlelo zebhayoloji.

imikhiqizo ehlobene

Boc-N-Me-L-Phe-OH N-Me-D-Phe Fmoc-N-Me-L-Phe-OH BOC-N-Me-D-Phe-OH
FMOC-N-Me-D-Phe-OH Boc-N-Me-L-Phe-OH.DCHA I-Boc-DN-Me-Phe.I-DCHA Fmoc-N-Me-D-Leu-OH
I-Boc-N-Me-DL-Phe-OH HN-Me-L-Phe-OH HN-Me-L-Phe.Hcl  

Kungani Khetha Thina

1. Mayelana ne-MOQ: Singayilungisa ngokuvumelana nemfuneko yakho.
2. Mayelana nesampula: Isampula idinga imali yesampula, okungaba yimpahla ongayilanda noma ongayikhokha kithi kusengaphambili.
3. I-Mold workshop, ingenziwa ngezifiso ngokusho kwenani lamamodeli.
4. Sinikeza isevisi engcono kakhulu.Ithimba labadayisi abanolwazi selisebenzela wena.
5. Mayelana nokushintshisana: Ngicela ungithumele i-imeyili noma ungixoxele ngesikhathi esivumelana nawe.


  • Okwedlule:
  • Olandelayo:

  • Bhala umyalezo wakho lapha futhi usithumelele wona