I-China 294855-91-7 Pal-Glu(OSU)-OH Umkhiqizi kanye Nemboni |Jiayinglai

294855-91-7 Pal-Glu(OSU)-OH

Incazelo emfushane:

Ukubukeka	Impushana emhlophe ukuya kokumhlophe
MF	I-C25H42N2O7
MW	482.61
Ubumsulwa	98+

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Isimo sezokuthutha
Kungaba kuzinga lokushisa elijwayelekile

Ncoma indlela yokuthumela
Ngomoya Ngomhlaba Ngasolwandle

Isimo sesitoreji:
Gcina endaweni emnyama, emkhathini ongangeni, izinga lokushisa legumbi

impilo yeshelufu
Cishe iminyaka emi-2

Ubuncane be-oda Ubuningi:
1kg (ingxoxo)

Isitifiketi:I-COA, indawo encibilikayo, i-SpecificRotation [α]_D²⁰

Sizothumela noma iyiphi idatha oyifunayo.Ungabona idatha ngaphambili njengereferensi.

Ngemikhiqizo eyenziwe ngokwezifiso, sithumela idatha entsha kakhulu ngemuva kokuthi iphumile.

Omqondofana

I-Liraglutidesidechain;

I-Pal-Glu(OSu)-OH;

I-Liraglutideintermediate;

(S) -5-((2,5-dioxopyrrolidin-1-yl)oxy) -5-oxo-2-palmitamidopentanoicacid;

(S) -5-(2,5-dioxopyrrolidin-1-yl)oxy) -2-palmitamidopentanoicacid;

(S)-5-((2,5-dioxopyrrolidin-1-yl)oxy)-5-oxo-2-palm;L-Glutamicacid,N-(1-oxohexadecyl)-,5-(2,5-dioxo -1-pyrrolidinyl) ester;

I-Nα-Palmitoyl-(L)-glutamicacid-γ-succinimidyl-α-tert-butylester

Ukupakisha kwangaphakathi

Zivame ukusetshenziselwa ukupakisha impushana.Kuya ngemfuneko yamakhasimende.Ngakho-ke, sitshele ngenkani yakho ngaphambi kokupakisha uma unezicelo ezikhethekile.

ukupakisha kwangaphandle

1kg kuya ku-25kg Ukupakisha kwangaphandle kunzima.Futhi kunzima ukusika nokulimaza.Ingavikela imikhiqizo yakho ngokuphelele.

Izinhlelo zokusebenza

I-Pal-Glu(OSU)-OH, eyaziwa nangokuthi i-liraglutide side chain, iyinhlanganisela yamakhemikhali ebalulekile enohlu olubanzi lwezinhlelo zokusebenza emikhakheni ehlukahlukene.

Okokuqala, emikhakheni ye-bioscience nemithi, i-Pal-Glu(OSU)-OH isetshenziswa njengeketango elisemaceleni lama-agonists e-glucagon-like peptide-1 (GLP-1).Ama-agonists e-GLP-1 receptor adlala indima ebalulekile ocwaningweni lohlobo 2 lwesifo sikashukela.Ngokubophezela ku-endo native metabolic hormone GLP-1, lawa ma-agonists ashukumisa ukukhiqizwa kwe-insulin futhi avimbele ukukhiqizwa kwe-glucagon, ngaleyo ndlela asize ekulawulweni kwamazinga kashukela egazini.Ngakho-ke, i-Pal-Glu(OSU)-OH inenani elibalulekile ekuthuthukisweni kwemithi yokwelapha isifo sikashukela.

Okwesibili, i-Pal-Glu(OSU)-OH iphinde isetshenziswe njengempahla eluhlaza yezidakamizwa ze-polypeptide ezisebenza isikhathi eside.Izakhiwo zayo zamakhemikhali eziyingqayizivele ziyenza ikwazi ukubamba iqhaza ekwakhiweni kwezakhiwo ze-peptide ezinemisebenzi ethile yebhayoloji, ihlinzeka ngamathuba amasha okwakhiwa nokuthuthukiswa kwezidakamizwa.Le mithi ye-polypeptide inezicelo ezingase zibe khona ekwelapheni izifo ezihlukahlukene.

Ngaphezu kwalokho, i-Pal-Glu(OSU)-OH ingasetshenziswa ekulungiseleleni ezinye izinhlanganisela ezinemisebenzi ethile.Ngenxa yamaqembu ayo asebenzayo kanye nezakhiwo ezisebenzayo, isebenza njengesihluthulelo esimaphakathi ekwakhiweni kwama-molecule ayinkimbinkimbi, iqhubeke nokwandisa ukusetshenziswa kwayo kukhemistri, isayensi yezinto ezibonakalayo, neminye imikhakha ehlobene.

Kungani Khetha Thina

1. Mayelana ne-MOQ: Singayilungisa ngokuvumelana nemfuneko yakho.
2. Mayelana nesampula: Isampula idinga imali yesampula, okungaba yimpahla ongayilanda noma ongayikhokha kithi kusengaphambili.
3. I-Mold workshop, ingenziwa ngezifiso ngokusho kwenani lamamodeli.
4. Sinikeza isevisi engcono kakhulu.Ithimba labadayisi abanolwazi selisebenzela wena.
5. Mayelana nokushintshisana: Ngicela ungithumele i-imeyili noma ungixoxele ngesikhathi esivumelana nawe.

Okwedlule: 2460751-66-8 Fmoc-L-Lys[C20-OtBu-Glu(OtBu)-AEEA-AEEA]-OH

Olandelayo: 323587-47-9 (2S)-2-Amino-3-(tert-butoxy)propanamide hydrochloride

Bhala umyalezo wakho lapha futhi usithumelele wona