isibhengezo_sekhasi

66638-37-7 Boc-N-Me-L-Tyr(tbu)-OH

66638-37-7 Boc-N-Me-L-Tyr(tbu)-OH

Incazelo emfushane:

Ukubukeka impushana emhlophe
MF I-C19H29NO5
MW 351.44
Ubumsulwa 98+


Imininingwane Yomkhiqizo

Isimo sezokuthutha
Kungaba kuzinga lokushisa elijwayelekile

Ncoma indlela yokuthumela
Ngomoya Ngomhlaba Ngasolwandle

Isimo sesitoreji:
Gcina endaweni emnyama, emkhathini ongangeni, izinga lokushisa legumbi

Impilo yeshelufu
Cishe iminyaka emi-2

Ubuncane be-oda Ubuningi:
1kg (ingxoxo)

Isitifiketi:I-COA, indawo encibilikayo, i-SpecificRotation [α]D20                      

Sizothumela noma iyiphi idatha oyifunayo.Ungabona idatha ngaphambili njengereferensi.

Ngemikhiqizo eyenziwe ngokwezifiso, sithumela idatha entsha kakhulu ngemuva kokuthi iphumile.

I-D-Ls(tfa)-NCA (2)

Omqondofana

(Tert-Butoxy)CarbonylN-Me-Tyr(tBu)-OH;

(2R)-2-{[(tert-butoxy)carbonyl](methyl)amino}-3-[4-(tert-butoxy)phenyl]propanoicacid;

I-Boc-L-MeTyr(tBu)-OH;

I-N-Boc-N-methyl-O-tert-butyl-L-tyrosine;

L-Tyrosine,N-[(1,1-dimethylethoxy)carbonyl]-O-(1,1-dimethylethyl)-N-methyl-;

I-N-α-(t-Butoxycarbonyl)-N-α-methyl-O-(t-butyl)-L-tyrosine;

(S)-3-(4-(tert-Butoxy)phenyl)-2-((tert-butoxycarbonyl)(methyl)amino)propanoicacid

Ukupakisha kwangaphakathi

Zivame ukusetshenziselwa ukupakisha impushana.Kuya ngemfuneko yamakhasimende.Ngakho-ke, sitshele ngenkani yakho ngaphambi kokupakisha uma unezicelo ezikhethekile.

Ukupakisha kwangaphakathi 2
Ukupakisha kwangaphakathi 1
Ukupakisha kwangaphakathi 3

ukupakisha kwangaphandle

1kg kuya ku-25kg Ukupakisha kwangaphandle kunzima.Futhi kunzima ukusika nokulimaza.Ingavikela imikhiqizo yakho ngokuphelele.

Ukupakisha kwangaphandle 3
Ukupakisha kwangaphandle 2
Ukupakisha kwangaphandle 1

Izinhlelo zokusebenza

I-Peptide Synthesis:
I-Boc-N-Me-L-Tyr(Tbu)-OH iyi-amino acid evikelwe evame ukusetshenziswa ku-solid-phase peptide synthesis (SPPS) nezinye izindlela zokwenziwa kwe-peptide.Ngokuvikelwe kokubili kwe-N-terminal kanye namaqembu e-side-chain hydroxyl, igcina uzinzo ngesikhathi sokwelulwa kweketango le-peptide, igwema ukusabela okuseceleni okungadingeki.
Ngemuva kokuthi ukuhlanganiswa kwe-peptide chain synthesis sekuqediwe, amaqembu avikelayo angasuswa ngaphansi kwezimo ezifanele, adalule ama-amino mahhala namaqembu e-hydroxyl, ngaleyo ndlela anikeze i-peptide efunwayo noma amaprotheni.
Ubunjiniyela bamaprotheni:
Ebunjiniyela bamaprotheni, le amino acid evikelwe ingasetshenziswa ekuguquleni amaprotheni endaweni ethile.Ngokusabela i-Boc-N-Me-L-Tyr(Tbu)-OH enezindawo ezithile kuphrotheni, insalela ye-methylated tyrosine ingase yethulwe, iguqule izakhiwo nokusebenza kweprotheni.
Ukwakhiwa Nokuthuthukiswa Kwezidakamizwa:
I-methylated tyrosine ingase ibonise imisebenzi ethile yezinto eziphilayo noma izakhiwo ze-pharmacokinetic kumiklamo ethile yezidakamizwa.Ngokusebenzisa i-Boc-N-Me-L-Tyr(Tbu)-OH njengebhulokhi yokwakha, abacwaningi bangahlola amandla okwelapha angaba khona kanye nezakhiwo zekhemisi zamangqamuzana ezidakamizwa aqukethe i-methylated tyrosine.
Ucwaningo lwe-Biochemical and Biological:
Ocwaningweni lwe-biochemical and biological, le-amino acid evikelwe ingasebenza njengenhlanganisela yethuluzi lokufunda indima ye-methylated tyrosine ekusebenzisaneni kwamaprotheni, ukudluliselwa kwesignali, umsebenzi we-enzyme, nezinye izici.
I-Bioconjugation kanye nokulebula:
Amaqembu e-methyl kanye nama-hydroxyl avikelwe we-Boc-N-Me-L-Tyr(Tbu)-OH akwenza kube ukukhetha okuhle kokusabela kwe-bioconjugation nokulebula.Ngokususa amaqembu avikelayo futhi asabelane namanye ama-molecule noma izinto eziphilayo, ama-molecule anelebula anemisebenzi ethile yebhayoloji angalungiselelwa.

imikhiqizo ehlobene

N-Me-Tyr(Mina)-OH FMOC-N-Me-D-Tyr(mina)-OH I-Fmoc-N-Me-L-Tyr(tBu)-OH Cbz-N-Me-Tyr(tbu)-OH
I-Fmoc-N-Me-D-Tyr(tBu)-OH I-Boc-N-Me-L-Tyr(bzl)-OH I-Fmoc-N-Me-L-Tyr(bzl)-OH I-Boc-N-Me-D-Tyr(bzl)-OH

Kungani Khetha Thina

1. Mayelana ne-MOQ: Singayilungisa ngokuvumelana nemfuneko yakho.
2. Mayelana nesampula: Isampula idinga imali yesampula, okungaba yimpahla ongayilanda noma ongayikhokha kithi kusengaphambili.
3. I-Mold workshop, ingenziwa ngezifiso ngokusho kwenani lamamodeli.
4. Sinikeza isevisi engcono kakhulu.Ithimba labadayisi abanolwazi selisebenzela wena.
5. Mayelana nokushintshisana: Ngicela ungithumele i-imeyili noma ungixoxele ngesikhathi esivumelana nawe.


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