HN-Me-L-Phe.Hcl

I-HN-Me-L-Phe-HCl, eyaziwa nangokuthi i-N-methyl-L-phenylalanine hydrochloride, iyinhlanganisela ebalulekile enezinhlobonhlobo zezinhlelo zokusebenza ku-biochemistry, ukutholakala kwezidakamizwa, ukuhlanganiswa kwe-peptide, kanye nobunjiniyela bamaprotheni.

I-Peptide Synthesis kanye nobunjiniyela bamaprotheni:
I-HN-Me-L-Phe-HCl iyingxenye ebalulekile ekuhlanganiseni kwe-peptide, ikakhulukazi uma kufunwa ukwethulwa kwezinsalela ze-N-methylated phenylalanine.Ngenxa yesakhiwo sayo samakhemikhali, ingahlanganiswa namanye ama-amino acid ukwakha ama-peptide noma amaprotheni anohlelo olukhethekile nemisebenzi.Lawa ma-peptide noma amaprotheni angase abe namandla okwelapha, njengama-enzyme inhibitors, ama-receptor antagonists, izici zokukhula, nokuningi.
Ukutholwa Kwezidakamizwa:
I-HN-Me-L-Phe-HCl isebenza njengesakhiwo esibalulekile sokuhlanganisa ama-peptide namaphrotheni asebenza ngokwebhayoloji.Ngokuyihlanganisa ngokulandelana kwe-peptide, ama-peptide e-bioactive noma amaprotheni angahlanganiswa, angase asebenze njengezidakamizwa emisha noma izandulela zezidakamizwa.Isibonelo, ingasetshenziswa ekuhlanganiseni ama-peptide e-antimicrobial, ama-peptide e-antiviral, ama-peptide e-antitumor, namanye ama-molecule ahlobene nokwelashwa.
Ucwaningo lwe-Biochemical:
Ezifundweni zamakhemikhali ezinto eziphilayo, i-HN-Me-L-Phe-HCl ingasetshenziswa njenge-reagent yokulebula yama-peptide noma amaprotheni.Ukwethulwa kwayo ochungechungeni lwe-peptide kuvumela ukulandelela okulula nokutholwa kwe-peptide noma ukuziphatha nokusebenza kwamaprotheni.Lokhu kuwusizo kakhulu ekutadisheni ukusebenzisana kwamaprotheni namaprotheni, ukugoqa amaprotheni, ukuqina kwamaprotheni, nezinye izici ze-protein biochemistry.
Ama-ejenti okuxilonga kanye ne-Biological Probes:
I-HN-Me-L-Phe-HCl ingasetshenziswa futhi ekuhlanganiseni ama-biological probes nama-ejenti okuxilonga.Ngenxa yokwakheka kwayo kwamakhemikhali athile kanye nokuguquguquka, ingasetshenziswa ukulebula ama-biomolecules anjengamasosha omzimba, ama-enzyme, noma ama-nucleic acid ukuze asetshenziswe ekuxilongweni kwesifo, ukuthwebula isithombe sebhayoloji, noma ukuhlolwa kwezidakamizwa.
I-Chiral Synthesis:
Njengenhlanganisela ye-chiral, i-HN-Me-L-Phe-HCl idlala indima ebalulekile ekuhlanganisweni kwe-chiral.Izinhlanganisela ze-Chiral zibaluleke kakhulu ekutholweni kwezidakamizwa njengoba zivame ukubonisa imisebenzi yebhayoloji eyingqayizivele.Ngokusebenzisa i-HN-Me-L-Phe-HCl njengomthombo we-chiral, i-chirality yama-peptide noma amaprotheni ngesikhathi sokuhlanganiswa kungalawulwa, okuholela ekukhiqizweni kwemikhiqizo ye-bioactive nemisebenzi oyifunayo.