... I-China 87512-31-0 I-Fluorene methoxy carbonyl-L-ALANYL-L-ALANINE Umkhiqizi kanye Nemboni |Jiayinglai
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87512-31-0 I-Fluorene methoxy carbonyl-L-AANYL-L-ALANINE

87512-31-0 I-Fluorene methoxy carbonyl-L-ALANYL-L-ALANINE Isithombe Esifakiwe
  • 87512-31-0 I-Fluorene methoxy carbonyl-L-AANYL-L-ALANINE
  • 87512-31-0 I-Fluorene methoxy carbonyl-L-AANYL-L-ALANINE
  • 87512-31-0 I-Fluorene methoxy carbonyl-L-AANYL-L-ALANINE

87512-31-0 I-Fluorene methoxy carbonyl-L-AANYL-L-ALANINE

Incazelo emfushane:

Ukubukeka Amakristalu amhlophe kuya kokumhlophe noma impushana ecwebezelayo.
MF I-C21H22N2O5
MW 382.41
Ubumsulwa 98+


Imininingwane Yomkhiqizo

Isimo sezokuthutha&indlela yokuthumela enconyiwe:
?

Isimo sesitoreji:
Ivalwe endaweni eyomile, engu-2-8°C

Ubuncane be-oda Ubuningi:
Ukuxoxisana

Isitifiketi:
I-COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyatholakala

I-D-Ls(tfa)-NCA (2)

Omqondofana

FMOC-ALA-ALA-OH;
Fmoc-L-Ala-L-Ala-OH;
(S)-2-((S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)propanamido)propanoic acid;
Fmoc-Ala-Ala-OH99%;
i-FMoc-Ala-Ala;
FMOC-ALA-ALA-OH;
FMOC-L-ALANYL-L-ALANINE;
I-FMoc-AA-OH;
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-alanine

Ukupakisha kwangaphakathi

Ngokuvamile zisetshenziselwa ukupakisha impushana.Futhi zingavimbela ukukhanya kwelanga namanzi ukuba kungabi kubi.

ukupakisha kwangaphandle

Ibhokisi eliqinile lingavikela imikhiqizo yakho ukuthi ingaphahlazeka futhi ibe manzi.

Izinhlelo zokusebenza

Lo mkhiqizo uyi-polypeptide eyakhiwe ngama-amino acid angama-28.Okwe-N - acetyl - L - usilika ammonia acyl - L - alpha amino ammonia acyl - L - propylene ammonia acyl - L - propylene ammonia acyl - L - valerian ammonia acyl - L - alpha amino ammonia acyl - L - Sue ammonia acyl - L - wire ammonia acyl - L - wire ammonia acyl - L - alpha glutamine - L - ukukhanya okuhlukile ammonia acyl - L - Sue ammonia acyl - L - Sue ammonia acyl - L - lai ammonia acyl - L - alpha amino ammonia acyl - L - ammonia acyl ekhanyayo - L - lai ammonia acyl - L - alpha - glutamine - L - lai ammonia acyl - L - lai ammonia acyl - L - alpha glutamine - L - valerian ammonia acyl - L - valerian ammonia acyl - L - alpha glutamine - L - alpha - glutamine - L - propylene ammonia iwayini - L - alpha - glutamine - L - asparagine.Ngokwezibalo ze-anhydrous ne-acetic-free substance, indlela equkethe i-thymus (C129 H215 N33O55) kufanele ibe ngu-95.0% ~ 105.0%.
Lo mkhiqizo uyimpushana emhlophe noma emhlophe noma isisindo esixekethile.
Lo mkhiqizo uncibilika ku-trifluoroacetic acid, uncibilika kancane emanzini, ongancibiliki ku-acetonitrile, ether kanye ne-trichloromethane.
Thatha lo mkhiqizo, ukale kahle, engeza u-0.02mol/L we-phosphate buffer solution (pH 7.0)(thatha u-2.72g we-potassium dihydrogen phosphate, engeza u-0.1mol/L we-sodium hydroxide solution 116.4ml ukuze uhlakaze, uhlambulule ngamanzi ku-1000ml) bese wenza isisombululo esiqukethe cishe i-5mg ku-1ml ngayinye.Inqunywa ngokomthetho (Isithasiselo ⅥE Sengxenye II ye-Pharmacopoeia, uhlelo lwango-2010), i-curl ethile kufanele ibe -100.0° ukuya ku- -110.0° ngokususelwe ekubalweni kwezinto ezingenayo i-acetic ne-anhydrous.
Indlela yokusebenza yalo mkhiqizo ekwelapheni isifo sokusha kwesibindi kohlobo B esingapheli kanye nokuthuthukisa ukusebenza kabusha kwamasosha omzimba ayikacaciswa ngokugcwele.Ukuhlolwa okuningi kwe-in vitro kubonise ukuthi lo mkhiqizo ungakhuthaza ukuvuthwa kwama-lymphocyte e-T ngokuvuselela i-mitogen yama-lymphocyte egazi angaphandle, ukwandisa amazinga e-interferon α, i-interferon γ, i-interleukin 2, i-interleukin 3 nezinye izici ze-lymphatic ezifihliwe ngamaseli T. emva kokusebenza kwe-antigen noma i-mitogen, futhi ngesikhathi esifanayo ukwandisa izinga lama-lymphofactor receptors ebusweni bamaseli e-T.Kungase futhi kuthuthukise ukusabela kwe-allogeneic kanye ne-autologous human lymphocyte exubile ngokwenza kusebenze amaseli e-CD4.Lo mkhiqizo ungase ukhulise ukuhlanganiswa kwamaseli e-pre-NK, futhi i-interferon ingase ikhulise i-cytotoxicity.Ukuhlolwa kwe-vivo kubonise ukuthi lo mkhiqizo ungakhuphula izinga lokuvezwa kwe-interleukin-2 receptor kanye nezinga lemfihlo le-interleukin-2 kuma-lymphocyte egundane ngemva kokusebenza kwe-cancanadin A.

imikhiqizo ehlobene

I-Gly-Ala-Ome.hcl Fmoc-L-Ala-OH β-Ala-Ome.HCl L-Ala-Phe-OH
I-Gly-Gly-Ala-Ome.hcl I-Fmoc-DL-Ala HL-Ala-Ome.Hcl L-Ala-Leu-OH
L-ALA Fmoc-D-Ala-OH β-Ala-Otbu.HCl I-L-Ala-Pro-OH
DL-ALA I-Fmoc-β-Ala-OH I-DL-Ala-Otbu.Hcl I-DL-Ala-DL-Val
H-Ala-ol Fmoc-LN-Me-Ala-OH L-Ala-NH2.HCl I-Ala-Gly-Ome.hcl
β-Ala-ol Fmoc-N-Me-D-Ala-OH I-HD-Ala-NH2·HCl L-Ala-Ala-Obzl.HCl
D-ALA I-Fmoc-Ala-Cl I-HD-Ala-NH2 I-D-Ala-D-Ala-Ome.Hcl
H-β-Ala-OH I-Fmoc-L-Ala-Ol I-Ac-L-Ala-NH2 H-Ala-Ala-Otbu.HCL
HN-Me-L-Ala-OH fmoc-β-Ala-NH2 I-Ac-D-Ala-NH2 Boc-Ala-Phe-OH
HN-Me-D-Ala-OH Fmoc-Ala-Ome AC-D,L-Ala-OH Boc-L-Ala-Leu
I-L-Ala-NCA Fmoc-Ala-Osu I-Ac-D-Ala-OH I-Boc-ALA-Val-OH
I-D-Ala-NCA fmoc-β-Ala-osu AC-L-Ala-OH I-Boc-Ala-Pro
L-Ala-nbu.hcl Cbz-L-Ala-OH AC-L-Ala-OME I-Boc-Ala-Gly-OH
L-Ala-Otbu Cbz-D-Ala-OH Pht-D-Ala I-Boc-Ala-Ala-OH
I-D-ALA-Oipr.HCL Cbz-N-Me-L-Ala-OH Pht-L-Ala Boc-Ala-Ala-Ome
I-D-Ala-Otbu.Hcl Cbz-N-Me-D-Ala-OH I-Boc-L-Ala-OH I-Boc-Ala-Ala-Obzl
N-Me-L-Ala-OMe Cbz-DL-Ala-OH I-Boc-D-Ala-OH I-Fmoc-Ala-pro
I-HD-Ala-OBzl·HCl Z-β-L-Ala-OH I-Boc-DL-Ala-OH I-Fmoc-Ala-gly-OH
β-Ala-Obzl.Tos Cbz-L-Ala-OL I-Boc-β-Ala-OH Fmoc-L-Ala-Ala-OH
H-Ala-OBzl·HCl Cbz-L-Ala-NH2 Boc-N-Me-Ala-OH Fmoc-β-Ala-D-phe
HL-Ala-OBzl.Tos-OH Cbz-L-Ala-Ome I-Boc-N-Me-DL-Ala-OH I-Fmoc-β-Ala-D-Tyr (Et)
I-HD-Ala-Oet.HCl Cbz-D-Ala-OMe I-Boc-N-Me-D-Ala-OH Cbz-Ala-Val-OH
I-HL-ALA-Oipr.HCL Cbz-Beta-Ala-Ome I-Boc-L-Ala-Ol Cbz-L-Ala-Ala-OH
N-Me-Ala-Otbu.Hcl Cbz-β-Ala-Otbu I-Boc-D-Ala-Ol Cbz-Ala-Pro-OH
HL-Ala-OtBu·HCl Cbz-L-Ala-Osu I-Boc-DL-Ala-Ol Cbz-L-Ala-Leu-OH
H-DL-Ala-OMe.HCl Cbz-Beta-Ala-OSU I-Boc-Ala-NH2 Cbz-L-Ala-Ala-Ome
β-Ala-Oet.HCl Ala-Ala-OH I-Boc-D-Ala-NH2 I-Ala-Ala-Ome.HCL
N-Me-L-Ala-Ome.hcl Ala-gly I-Boc-β-Ala-NH2 I-Val-Ala
I-HD-Ala-Ome.Hcl L-ALA-Val-OH I-Boc-D-4-Chloropheny(alanine) I-Boc-Ala-Pro
I-Boc-L-ALA-OBZL Boc-Leu-Ala I-Boc-D-3(1-Naphthgl)-alanine I-Boc-Val-Ala
I-Boc-L-Ala-OSu Fmoc-leu-ala Boc-L-Ala-Ome Cbz-Val-Ala-OH
I-Boc-L-Beta-Ala-Osu Cbz-Leu-Ala-OH I-Boc-D-Ala-OMe Cbz-Val-Ala-Ome
I-Boc-D-Ala-OSu Phe-Ala I-Boc-L-Ala-Otbu Leu-Ala-OH
Fmoc-L-Ala-OH.H2O Boc-Phe-Ala-OH Z-Lys(boc)-Ala-Ala-OBzl I-HL-Thr-OBzl·oxalate
I-HL-Thr(Bzl)-OBzl.oxalate Cbz-Phe-Ala-OH  

Ukuphakama

1. Isevisi ye-R&D iyatholakala
2. Umkhiqizi oqinisekisiwe we-ISO, isiqinisekiso sekhwalithi
I-3.Inkambo ephelele yenkonzo yokulandelela ngesikhathi sokukhiqiza
I-4.Izindleko eziphezulu
5.Imibhalo yesitifiketi sekhwalithi enikeziwe ngokwesicelo sekhasimende ngalinye
I-6.Isevisi enhle emva kokuthengisa, ukugcina ubuhlobo obuseduze nekhasimende
7.Insiza egcwele yokusiza ukwehlisa izindleko zokuthumela
8.Isampula yamahhala enikelwe ukuhlola ikhwalithi ngaphambi kwanoma iyiphi inkokhelo
9.Isikhathi sokukhokha okuxoxiswana ngaso
10.Amakhasimende e-Assit abhekana nezindaba zaseShayina

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