I-China 2013-12-9 D(-)-Norvaline Umkhiqizi kanye Nemboni |Jiayinglai

2013-12-9 D(-)-Norvaline

Incazelo emfushane:

Ukubukeka	Okumhlophe kuya kokumhlophe
MF	I-C5H11NO2
MW	117.15
Ubumsulwa	98+

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Isimo sezokuthutha&indlela yokuthumela enconyiwe:
ngomoya, ngolwandle noma nge-express

Isimo sesitoreji:
2-8°C

Ubuncane be-oda Ubuningi:
Ukuxoxisana

Isitifiketi:
I-COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyatholakala

Omqondofana

I-HD-NVA-OH;

I-HD-NHCH[CH3(CH2)2]-COOH;

I-HD-NORVALINE;

I-HD-APE(2)-OH;

I-D-Nval-OH;

I-HD-2-AMINOVALERIC ACID;

D-Nva-OH;

I-D-Nval

Ukupakisha kwangaphakathi

Ngokuvamile zisetshenziselwa ukupakisha impushana.Futhi zingavimbela ukukhanya kwelanga namanzi ukuba kungabi kubi.

ukupakisha kwangaphandle

Ibhokisi eliqinile lingavikela imikhiqizo yakho ukuthi ingaphahlazeka futhi ibe manzi.

Izinhlelo zokusebenza

Ingasetshenziselwa ukwenza i-D-Glu.Ama-d-aminoacids ahlukahlukene, afana ne-D-serine, i-D-aspartic acid(D-Asp), kanye ne-D-glutamicacid (D-Glu) atholakala kabanzi ezilwaneni ezincelisayo okuhlanganisa nabantu futhi manje sekucatshangwa ukuthi zingamakhandidethi wenoveli esebenzayo ngokomzimba. izinto kanye/noma ama-biomarker.I-D-[Asp/Glu](4mg/mL) ivimbela ukubophezela kwe-IgE (75%) kumakinati kuyilapho i-D-Glu , i-D-Asp ingenawo umthelela ovimbelayo.I-IgE icaciselwe i-D-[Asp/Glu] futhi ingase ibe namandla okukhipha i-IgE noma yehlise ukubophezela kwe-IgE ezintweni ezingezwani nephenathi.

I-D-glutamicacid njengamanje inakwa njengemoduli yokudluliselwa kwe-neuronal kanye nokukhiqizwa kwamahomoni.I-metabolized kuphela yi-D-aspartate oxidase ezilwaneni ezincelisayo.Ngemuva komjovo we-intraperitoneal, i-L-glutamate ikhishwa nge-a-ketoglutarate, kuyilapho i-D-glutamate iguqulelwa ku-n-pyrrolidone carboxylic acid.I-Carbon2 yakho kokubili i-D- ne-L-glutamate iguqulwa ku-cecum ibe yi-methyl carbon ye-acetate.Kokubili isibindi segundane nezinso zenza ukuguqulwa kwe-D-glutamicacid ibe yi-n-pyrrolidone carboxylic acid.

imikhiqizo ehlobene

I-L-Nval-OH	I-Fmoc-N-Me-L-Nval-OH
Fmoc-D-NvaL-OH	I-Boc-Nval-OH
I-Boc-D-Nval-OH	I-Boc-D-Nval-DCHA

Ukuphakama

1. Isevisi ye-R&D iyatholakala
2. Umkhiqizi oqinisekisiwe we-ISO, isiqinisekiso sekhwalithi
I-3.Inkambo ephelele yenkonzo yokulandelela ngesikhathi sokukhiqiza
I-4.Izindleko eziphezulu
5.Imibhalo yesitifiketi sekhwalithi enikeziwe ngokwesicelo sekhasimende ngalinye
I-6.Isevisi enhle emva kokuthengisa, ukugcina ubuhlobo obuseduze nekhasimende
7.Insiza egcwele yokusiza ukwehlisa izindleko zokuthumela
8.Isampula yamahhala enikelwe ukuhlola ikhwalithi ngaphambi kwanoma iyiphi inkokhelo
9.Isikhathi sokukhokha okuxoxiswana ngaso
10.Amakhasimende e-Assit abhekana nezindaba zaseShayina